Antibacterial activity of antibiotic-soaked polyvinylpyrrolidone-grafted silicon elastomer hydrocephalus shunts
Autor: | Jaap Jan Boelens, Wee-Fu Tan, Sebastian A. J. Zaat, Jacob Dankert |
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Přispěvatelé: | Other departments |
Jazyk: | angličtina |
Rok vydání: | 2000 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Micrococcaceae medicine.drug_class Staphylococcus Antibiotics Pharmacology Dosage form Bacterial Adhesion Staphylococcus epidermidis medicine Pharmacology (medical) Antibacterial agent biology Polyvinylpyrrolidone Bacteria Chemistry Povidone Antimicrobial biology.organism_classification Surgery Anti-Bacterial Agents Infectious Diseases Silicone Elastomers Antibacterial activity medicine.drug Hydrocephalus |
Zdroj: | Journal of antimicrobial chemotherapy, 45(2), 221-224. Oxford University Press |
ISSN: | 0305-7453 |
DOI: | 10.1093/jac/45.2.221 |
Popis: | If shunts, inserted for the relief of hydrocephalus, are pretreated with antimicrobials, the incidence of shunt-associated infections (SAI) may be reduced. The duration of the antibacterial activity of shunts, made from conventional silicon elastomer (SE) or from SE grafted with the hydrogel polyvinylpyrrolidone (SEpvp), which had been soaked in various antibiotics, was assessed in vitro. For any antibiotic or combination, using an arbitrary breakpoint (aBP), SEpvp remained antibacterially active for longer periods than SE. Bacterial adherence to either shunt was prevented during the period of antibacterial activity. Thus, the aBP is a good indicator of the capacity of antimicrobial-treated shunts to prevent bacterial colonization in vitro. Hydrogel-grafting of shunts may be useful in preventing SAI. |
Databáze: | OpenAIRE |
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