Cardiovascular Disease Risk Factor Burden During the Menopause Transition and Late Midlife Subclinical Vascular Disease: Does Race/Ethnicity Matter?

Autor: Samar R. El Khoudary, Carol A. Derby, Chunzhe Duan, Emma Barinas-Mitchell, Rebecca C. Thurston, Elizabeth A. Jackson, Tené T. Lewis, Karen A. Matthews, Maria M. Brooks
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Gerontology
Carotid Artery Diseases
Male
Race ethnicity
cardiovascular disease risk factors
Social Determinants of Health
Ethnic group
menopause
Disease
030204 cardiovascular system & hematology
race and ethnicity
0302 clinical medicine
Risk Factors
Cardiovascular Disease
Ethnicity
Longitudinal Studies
Prospective Studies
Subclinical infection
Original Research
Age Factors
Hispanic or Latino
Middle Aged
3. Good health
Race Factors
Menopause
Female
women
Cardiology and Cardiovascular Medicine
Risk Assessment
White People
03 medical and health sciences
Sex Factors
Disease risk factor
medicine
Humans
Aged
Go Red for Women Spotlight
Cultural Characteristics
Asian
Vascular disease
business.industry
Cardiometabolic Risk Factors
medicine.disease
United States
Black or African American
Menopause transition
Asymptomatic Diseases
atherosclerosis
business
030217 neurology & neurosurgery
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background The extent to which cardiovascular disease ( CVD ) risk factors across the menopause explain racial/ethnic differences in subclinical vascular disease in late midlife women is not well documented and was explored in a multi‐ethnic cohort. Methods and Results Participants (n=1357; mean age 60 years) free of clinical CVD from the Study of Women's Health Across the Nation had common carotid artery intima‐media thickness, interadventitial diameter, and carotid plaque presence assessed by ultrasonography on average 13.7 years after baseline visit. Early to late midlife time‐averaged cumulative burden of traditional CVD risk factors calculated using serial measures from baseline to the ultrasound visit were generally less favorable in black and Hispanic women compared with white and Chinese women, including education and smoking status and time‐averaged cumulative blood pressure, high‐density lipoprotein cholesterol, and fasting insulin. Independent of these risk factors, BMI , and medications, common carotid artery intima‐media thickness was thicker in black women, interadventitial diameter was wider in Chinese women, yet plaque presence was lower in black and Hispanic women compared with white women. CVD risk factor associations with subclinical vascular measures did not vary by race/ethnicity except for high‐density lipoprotein cholesterol on common carotid artery intima‐media thickness; an inverse association between high‐density lipoprotein cholesterol and common carotid artery intima‐media thickness was observed in Chinese and Hispanic but not in white or black women. Conclusions Race/ethnicity did not particularly moderate the association between traditional CVD risk factors measured across the menopause transition and late midlife subclinical vascular disease. Unmeasured socioeconomic, cultural, and nontraditional biological risk factors likely play a role in racial/ethnic differences in vascular health and merit further exploration.
Databáze: OpenAIRE
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