Urinary apolipoprotein AI in children with kidney disease
| Autor: | Jianyong Zhong, Deborah P Jones, Liping Du, Amanda J. Clark, Valentina Kon, Kathy Jabs, Tracy E. Hunley, Carl Anderson, Haichun Yang, Rene G. VanDeVoorde, Agnes B. Fogo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nephrology
medicine.medical_specialty Kidney business.industry 030232 urology & nephrology Glomerulonephritis 030204 cardiovascular system & hematology medicine.disease Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Focal segmental glomerulosclerosis medicine.anatomical_structure Internal medicine Pediatrics Perinatology and Child Health medicine Polycystic kidney disease Minimal change disease Kidney disorder business Kidney disease |
| Zdroj: | Pediatr Nephrol |
| Popis: | BACKGROUND: Although high density lipoprotein (HDL) modulates many cell types in the cardiovascular system, little is known about HDL in the kidney. We assessed urinary excretion of apolipoprotein AI (apoAI), the main protein in HDL. METHODS: We enrolled 228 children with various kidney disorders and 40 controls. Urinary apoAI, albumin and other markers of kidney damage were measured using ELISA, apoAI isoforms with Western blot, and renal biopsies stained for apoAI. RESULTS: Patients followed in nephrology clinic had elevated urinary apoAI vs. controls (median 0.074 ug/mg; Interquartile Range (IQR): 0.0160–0.560, vs. 0.019 ug/mg; IQR: 0.004–0.118, p |
| Databáze: | OpenAIRE |
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