COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics

Autor: D Ly-Pen, J Saban-Ruiz
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Aging
medicine.medical_specialty
030309 nutrition & dietetics
Pneumonia
Viral
Management of heart failure
Population
Medicine (miscellaneous)
Comorbidity
Disease
Article
endothelial dysfunction
Coronary artery disease
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
cardiometabolic risk
atherothrombotic disease
Diabetes Mellitus
Humans
Medicine
030212 general & internal medicine
Precision Medicine
Intensive care medicine
education
Pandemics
Aged
Metabolic Syndrome
0303 health sciences
education.field_of_study
Nutrition and Dietetics
SARS-CoV-2
business.industry
COVID-19
Immunosenescence
medicine.disease
Cardiovascular Diseases
Infectious disease (medical specialty)
Heart failure
cardiometabolic syndrome
Geriatrics and Gerontology
Coronavirus Infections
business
cardiometabolic health
Zdroj: The Journal of Nutrition, Health & Aging
The journal of nutrition, health & aging
ISSN: 1760-4788
1279-7707
Popis: COVID 19 is much more than an infectious disease by SARS-CoV-2 followed by a disproportionate immune response. An older age, diabetes and history of cardiovascular disease, especially hypertension, but also chronic heart failure and coronary artery disease among others, are between the most important risk factors. In addition, during the hospitalization both hyperglycaemia and heart failure are frequent. Less frequent are acute coronary syndrome, arrhythmias and stroke. Accordingly, not all prolonged stays or even deaths are due directly to SARS-CoV-2. To our knowledge, this is the first review, focusing both on cardiovascular and metabolic aspects of this dreadful disease, in an integrated and personalized way, following the guidelines of the Cardiometabolic Health/Medicine. Therefore, current personalized aspects such as ACEIs and ARBs, the place of statins and the most appropriate management of heart failure in diabetics are analysed. Aging, better than old age, as a dynamic process, is also considered in this review for the first time in the literature, and not only as a risk factor attributed to cardiovascular and non-cardiovascular comorbidities. Immunosenescence is also approached to build healthier elders, so they can resist present and future infectious diseases, and not only in epidemics or pandemics. In addition, to do this we must start knowing the molecular mechanisms that underlying Aging process in general, and immunosenescence in particular. Surprisingly, the endoplasmic reticulum stress and autophagy are implicated in both process. Finally, with a training in all the aspects covered in this review, not only the hospital stay, complications and costs of this frightening disease in high-risk population should be reduced. Likely, this paper will open a gate to the future for open-minded physicians.
Databáze: OpenAIRE
Externí odkaz: