Meningeal carcinomatosis: development of an experimental model
| Autor: | Yukitaka Ushio, William R. Shapiro, Norman L. Chernik, Jerome B. Posner |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors Neurological disability Suspension culture Pathology and Forensic Medicine Cellular and Molecular Neuroscience Meninges Carcinoma medicine Animals Spinal Cord Neoplasms Carcinoma 256 Walker Neoplasm Metastasis Experimental model business.industry Brain Neoplasms Cancer General Medicine medicine.disease Chemotherapy regimen Pathophysiology Rats Disease Models Animal Meningeal carcinomatosis Neurology Female Neurology (clinical) business |
| Zdroj: | Journal of neuropathology and experimental neurology. 36(2) |
| ISSN: | 0022-3069 |
| Popis: | An experimental model of meningeal carcinomatosis has been produced by intracisternal inoculation of Walker 256 carcinoma cell suspension into Wistar rats. The tumor grows rapidly and is fatal in about 15 days if 10(6) cells are injected. The histopathological pattern observed is similar to that seen in diffuse leptomeningeal involvement of systemic cancer in human beings. The model will be useful for investigating the pathophysiology of the neurological disability produced by meningeal carcinomatosis and the efficacy of chemotherapeutic agents. |
| Databáze: | OpenAIRE |
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