Epstein–Barr Virus (EBV) MicroRNAs: Involvement in Cancer Pathogenesis and Immunopathology
| Autor: | Leandra Fiori Lopes, Ionice Felipe, Karina de Almeida Gualtieri, Maria Angelica Ehara Watanabe, Ivete Conchon Costa, Wander Rogério Pavanelli, Karla G. G. Serafim, Kenji William Ruiz Miyazawa, Elaine Regina Delicato de Almeida |
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| Rok vydání: | 2013 |
| Předmět: |
Untranslated region
Epstein-Barr Virus Infections Herpesvirus 4 Human Immunology Biology medicine.disease_cause Virus Neoplasms microRNA medicine Humans Immunology and Allergy Gene silencing Gene Silencing 3' Untranslated Regions Genetics Regulation of gene expression B-Lymphocytes Three prime untranslated region Cell Transformation Viral Virology Epstein–Barr virus Gene Expression Regulation Neoplastic MicroRNAs RNA Viral Carcinogenesis |
| Zdroj: | International Reviews of Immunology. 32:271-281 |
| ISSN: | 1563-5244 0883-0185 |
| DOI: | 10.3109/08830185.2012.748053 |
| Popis: | The Epstein-Barr virus (EBV), which infects over 90% of adults, appears to have evolved to exploit the normal biology of B-cell development in order to persist as a life-long asymptomatic infection. However, EBV can contribute to oncogenesis. It has become evident that alterations in the expression of microRNAs (miRNAs) from the host cell and EBV can also contribute to cancer pathogenesis. MicroRNAs function by inhibiting translation of select groups of mRNA transcripts containing imperfect annealing sequences in their 3' untranslated regions (3' UTRs) and less frequently through other regions of the transcript. A number of studies have demonstrated that profiles of miRNA expression could establish phenotypic signatures of different cancer types where viruses have been evolved with highly sophisticated gene silencing machinery to disturb the host-immune response. Based on current review, it is possible that a specific virus miRNA may be involved in cancer pathogenesis. |
| Databáze: | OpenAIRE |
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