β4 and β6 Integrin Expression Is Associated with the Subclassification and Clinicopathological Features of Intrahepatic Cholangiocarcinoma

Autor: Motoji Sawabe, Takumi Akashi, Yurie Soejima, Toshio Fukusato, Miho Takeuchi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Pathology
Cytoplasm
Integrins
intrahepatic cholangiocarcinoma
integrin
classifications
tenascin
laminin
TGF-β1
Bile Duct Neoplasm
Cholangiocarcinoma
lcsh:Chemistry
0302 clinical medicine
Laminin
lcsh:QH301-705.5
Spectroscopy
Intrahepatic Cholangiocarcinoma
Aged
80 and over
biology
Bile duct
General Medicine
Middle Aged
Computer Science Applications
Gene Expression Regulation
Neoplastic
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Adult
medicine.medical_specialty
Integrin
Tenascin
Down-Regulation
Catalysis
Article
Inorganic Chemistry
Transforming Growth Factor beta1
03 medical and health sciences
Antigens
Neoplasm
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
Integrin alpha6beta4
Organic Chemistry
Mucin
Mucins
030104 developmental biology
Bile Duct Neoplasms
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Transforming growth factor
Zdroj: International Journal of Molecular Sciences, Vol 19, Iss 4, p 1004 (2018)
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1004
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous group of cancers of the intrahepatic biliary tract. However, few studies have evaluated integrin expression according to an ICC subgroup. We immunohistochemically investigated α6β4 (β4) and αvβ6 (β6) integrin expressions in 48 ICCs, and evaluated their relationship with clinical and pathological parameters and ligand expression, as well as transforming growth factor (TGF)-β1. β4 and β6 expressions were detected in 46 (96%) and 35 (73%) ICC cases, respectively. We classified ICC into negative, low (β4, 29 cases; β6, 36 cases), or high (β4, 19 cases; β6, 12 cases) integrin expression groups. β4 and β6 integrin levels were higher in the non-peripheral central localization type ICC than in the peripheral localization type; they were also higher in the periductal-infiltrating or intraductal-growth types than in the mass-forming type ICC; lastly, they were higher in the well-differentiated type than in the poorly-differentiated type ICC. High expression was related to bile duct invasion. In addition, β4 and β6 expressions were associated with mucin production and the expression of cytoplasmic epithelial membrane antigen, laminin-5, and tenascin-C. TGF-β1 was correlated with β6 expression and poor overall survival. These results suggest that integrin expression is associated with subclassification and clinicopathological features of ICC through the coincident expression of their ligands and TGF-β1.
Databáze: OpenAIRE
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