De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy

Autor:	Hong-Shiue Chou, Ting-Jung Wu, Tsung-Han Wu, Chen-Fang Lee, Wei-Chen Lee, Kun-Ming Chan, Chih-Hsien Cheng
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Lipopolysaccharides Male Lipopolysaccharide Article Subject medicine.medical_treatment lcsh:Medicine Inflammation ATP-binding cassette transporter Pharmacology General Biochemistry Genetics and Molecular Biology Excretion 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Medicine Animals Hepatectomy ATP Binding Cassette Transporter Subfamily B Member 11 Autoantibodies General Immunology and Microbiology business.industry lcsh:R Autoantibody Transporter General Medicine Bacterial Infections Bile Salt Export Pump Mice Inbred C57BL Disease Models Animal chemistry Immunoglobulin M Liver 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology medicine.symptom business Research Article
Zdroj:	BioMed Research International, Vol 2018 (2018) BioMed Research International
ISSN:	2314-6141 2314-6133
Popis:	Background. Clinically severe infection-related inflammation after major liver resection may cause hyperbilirubinemia. This study aims to clarify the impact of bacterial infection and endotoxins on the hepatobiliary transporter system and to explore possible mechanisms of endotoxin-related postoperative hyperbilirubinemia.Method. Mice that underwent major hepatectomy with removal of at least 70% of liver volume were exposed to lipopolysaccharide (LPS) at different dosages. Subsequently, hepatobiliary transporter compounds related to bile salt excretion were further investigated.Results. The expression of genes related to hepatobiliary transporter compounds was not significantly different in the liver tissue of mice after major hepatectomy and LPS exposure. However, bile salt export pump (BSEP) protein expression within the liver tissue of mice treated with LPS after major hepatectomy was relatively weaker and was even further reduced in the high-dose LPS group. The formation of antibodies against the BSEP in response to endotoxin exposure was also detected.Conclusion. This study illustrates a possible mechanism whereby the dysfunction of hepatobiliary transporter systems caused by endotoxin-induced autoantibodies may be involved in the development of postoperative jaundice associated with bacterial infection after major hepatectomy.
Databáze:	OpenAIRE
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