Metabolic enzymes: key modulators of functionality in cancer stem-like cells
| Autor: | Yan Luo, Jian-Shan Mao, Bo-Wen Dong, Guang-Ming Qin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
cancer stem-like cells
0301 basic medicine Oncology medicine.medical_specialty enzymes Metabolic adaptation mechanism Review stemness 03 medical and health sciences 0302 clinical medicine Internal medicine Animals Humans Medicine Cellular metabolism Traditional medicine business.industry Mechanism (biology) Cancer medicine.disease 030104 developmental biology Metabolic enzymes 030220 oncology & carcinogenesis Cancer cell Neoplastic Stem Cells business metabolism Metabolic profile Signal Transduction |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.14041 |
| Popis: | // Bo-Wen Dong 1 , Guang-Ming Qin 2 , Yan Luo 3 , Jian-Shan Mao 1 1 Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China 2 Department of Clinical Laboratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China 3 School of Basic Medical Sciences, Zhejiang University, Hangzhou, China Correspondence to: Jian-Shan Mao, email: jshmao@zju.edu.cn Keywords: cancer stem-like cells, metabolism, enzymes, stemness, mechanism Received: August 02, 2016 Accepted: November 07, 2016 Published: December 20, 2016 ABSTRACT Cancer Stem-like Cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity and are important for the initiation, progression and recurrence of cancer diseases. The metabolic profile of CSCs is consistent with their stem-like properties. Studies have indicated that enzymes, the main regulators of cellular metabolism, dictate functionalities of CSCs in both catalysis-dependent and catalysis-independent manners. This paper reviews diverse studies of metabolic enzymes, and describes the effects of these enzymes on metabolic adaptation, gene transcription and signal transduction, in CSCs. |
| Databáze: | OpenAIRE |
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