Weight reduction regresses left ventricular mass regardless of blood pressure level in obese subjects
| Autor: | Yoshiyuki Nakashima, Kenji Nishino, Etsuro Himeno, Akio Kuroiwa, Masaharu Ikeda |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Anaerobic Threshold Diet Reducing Blood Pressure Body weight Left ventricular mass Risk Factors Weight loss Internal medicine Weight Loss medicine Humans Mild exercise Obesity business.industry Blood pressure level medicine.disease Exercise Therapy Endocrinology Echocardiography Case-Control Studies Decreased blood pressure Hypertension Female Hypertrophy Left Ventricular Obese subjects medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 131:313-319 |
| ISSN: | 0002-8703 |
| Popis: | The effects of weight reduction on left ventricular mass in obese normotensive and hypertensive subjects were investigated. Previous studies have shown that weight reduction in hypertensive (HT) obese patients is associated with decreased left ventricular mass (LVM) and decreased blood pressure (BP). This study was performed to examine whether weight reduction would also regress LVM in normotensive (NT) obese subjects and to clarify the mechanisms of these effects if they occurred. A weight-reduction program consisted of mild exercise and mild hypocaloric intake. M-mode echocardiography was performed to estimate the LVM. After the 12-week intervention, the mean reductions in body weight (BW) in the NT (n = 11) and HT (n = 11) groups were 4.9 kg (p0.005) and 4.6 kg (p0.0005), respectively. Systolic, diastolic, and mean BP were significantly reduced by 13, 9, and 11 mm Hg, respectively, in the HT group. By contrast, no significant changes in systolic, diastolic, or mean BP were observed in the NT group. LVM was significantly reduced from 176 +/- 26 gm to 159 +/- 26 gm (p0.05) in the HT group and from 167 +/- 33 gm to 145 +/- 34 gm (p0.02) in the NT group. These results suggest that weight reduction in obese subjects by mild exercise and mild hypocaloric intake can lead to a reduction in LVM, regardless of whether the subjects have normal or high blood pressure. |
| Databáze: | OpenAIRE |
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