Prostaglandin synthesis by murine mammary gland is modified by the state of the estrus cycle
| Autor: | Kathryn C. Watson, Sue C. Liu, Anna M. Cannizzaro, Meng F. Lim, Richard A. Knazek, Robert J. Christy |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Estrous cycle
endocrine system medicine.medical_specialty urogenital system Prostaglandins E Indomethacin Prostaglandins F Mammary gland Prostaglandin synthesis Biology Biochemistry Mice Mammary Glands Animal Endocrinology medicine.anatomical_structure Estrus Pregnancy Internal medicine medicine Animals Female hormones hormone substitutes and hormone antagonists reproductive and urinary physiology |
| Zdroj: | Prostaglandins. 19:891-897 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(80)90123-9 |
| Popis: | Mammary glands were excised from female C3H mice at various stages of their estrus cycle. Homogenates incubated at 37 degrees C +/- 10(5) M indomethacin synthesized prostaglandins (PG) E and f2 alpha at rates that varied as a function of the stage at estrus. The rate of PGF2 alpha synthesis was maximal at 1330 pg per mg protein per 2 hr in early diestrus and fell to undetectable levels in early estrus. PGE synthesis exhibited a similar pattern, being maximal at 83 pg per mg protein per 2 hr in early diestrus. These observations suggest that prostaglandins play a role in the cyclic changes observed within the mammary gland. |
| Databáze: | OpenAIRE |
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