Granulocyte colony‐stimulating factor with or without immunosuppression reduction in neutropenic kidney transplant recipients

Autor: Shaifali Sandal, Han Yao, Ahsan Alam, David D’ Arienzo, Dana Baran, Marcelo Cantarovich
Rok vydání: 2022
Předmět:
Zdroj: Clinical Transplantation. 36
ISSN: 1399-0012
0902-0063
Popis: Neutropenia post-kidney transplantation is associated with adverse graft and patient outcomes. We aimed to analyze the effect of granulocyte colony-stimulating factor (G-CSF) use with and without immunosuppression reduction on graft outcomes in neutropenic recipients.In this retrospective cohort study, we identified 120 recipients with neutropenia, within the first-year post-transplant.Of these, 45.0% underwent no intervention, 17.5% had immunosuppression reduced, 18.3% were only given G-CSF, and 19.2% had both interventions. Overall, 61 patients experienced the composite outcome of de-novo DSA, biopsy-proven acute rejection, and all-cause graft failure and the cumulative incidence of this outcome did not vary by any of the four interventions (p = .93). When stratifying the cohort by G-CSF use alone, those who received G-CSF were more likely to have had severe neutropenia (500/mmOverall, we conclude that G-CSF use with or without immunosuppression reduction was not associated with graft outcomes.
Databáze: OpenAIRE
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