The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture
| Autor: | Omar Trujillo, Camila Zolini, Carolina Silva-Carvalho, Silvia Fuselli, Eduardo Tarazona-Santos, Timothy D. O’Connor, Francesca Tassi, Victor Borda, Thiago P. Leal, Vinicius Furlan, Marilia O. Scliar, Meredith Yeager, Moara Machado, Carlos Padilla, Michael Dean, Giordano B. Soares-Souza, Robert H. Gilman, Gilderlanio S. Araújo, Marla Mendes, Isabela Alvim, Heinner Guio, Marcelo R. Luizon, Pedro E. Romero, Pedro O. Flores-Villanueva, Omar Cáceres, Roxana Zamudio, Kelly S. Levano, César Cabezas Sánchez |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Gene Flow
Rainforest Demographic history Natural selection Climate Amazonian media_common.quotation_subject Civilization Polymorphism Single Nucleotide Gene flow NO Gene Frequency Native Americans Human population genetics parasitic diseases Peru LS8_2 Humans Selection Genetic media_common Multidisciplinary Amazon rainforest Ecology Altitude Indians South American Empire Biological Sciences Adaptation Physiological Dual Oxidases Arid Human population genetics Native Americans Natural selection gene flow Genetics Population Geography Socioeconomic Factors Genetic structure Leukocyte Common Antigens RNA Long Noncoding Thyroid function T-Box Domain Proteins |
| Zdroj: | Proc Natl Acad Sci U S A |
| DOI: | 10.1101/2020.01.30.916270 |
| Popis: | Western South America was one of the worldwide cradles of civilization. The well known Inca Empire was the tip of the iceberg of a cultural and biological evolutionary process that started 14-11 thousand years ago. Genetic data from 18 Peruvian populations reveal that: (1) The between-population homogenization of the central-southern Andes and its differentiation with respect to Amazonian populations of similar latitudes do not extend northward. Instead, longitudinal gene flow between the northern coast of Peru, Andes and Amazonia accompanied cultural and socioeconomic interactions revealed by archeological studies. This pattern recapitulates the environmental and cultural differentiation between the fertile north, where altitudes are lower; and the arid south, where the Andes are higher, acting as a genetic barrier between the sharply different environments of the Andes and Amazonia (2). The genetic homogenization between the populations of the arid Andes is not only due to migration during the Inca Empire or the subsequent colonial period. It started at least during the earlier expansion of the pre-Inca Wari Empire (600-1000 YBP) (3) This demographic history allowed for cases of positive natural selection in the high and arid Andes vs. the low Amazon tropical forest: in the Andes, HAND2-AS1 (heart and neural crest derivatives expressed 2 antisense RNA1, related with cardiovascular function) and DUOX2 (dual oxidase 2, related to thyroid function and innate immunity) genes; in the Amazon, the gene encoding for the CD45 protein, essential for antigen recognition by T/B lymphocytes in viral-host interaction, consistent with the host-virus arms race hypothesis. |
| Databáze: | OpenAIRE |
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