p-Tyrosol Enhances the Production of New Neurons in the Hippocampal CA1 Field after Transient Global Cerebral Ischemia in Rats
| Autor: | M. Yu. Khodanovich, Marina S Kudabaeva, V. I. Smol’yakova, A. A. Kisel, Mark B. Plotnikov, Galina A. Chernysheva, Elena Krutenkova, Ya А Tyumentseva |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Aortic arch medicine.medical_specialty Doublecortin Protein Neurogenesis Ischemia Hippocampus Hippocampal formation Neuroprotection General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine.artery medicine Animals Rats Wistar CA1 Region Hippocampal Neurons biology General Medicine Phenylethyl Alcohol medicine.disease Nerve Regeneration Rats Tyrosol Disease Models Animal Neuroprotective Agents 030104 developmental biology Endocrinology nervous system chemistry Ischemic Attack Transient biology.protein NeuN 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:224-228 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04679-7 |
| Popis: | This study aimed at assessing the regenerative effect of p-tyrosol in transient global cerebral ischemia modeled in adult male Wistar rats by reversible occlusion of the three major vessels originating from the aortic arch and supplying the blood to the brain. p-Tyrosol was administered intraperitoneally in a dose of 20 mg/kg over 10 days after surgery. The death of NeuN+ mature neurons and the number of newly formed DCX+ neurons were assessed in the CA1 field of the hippocampus that is highly susceptible to damage in this model. We found that ischemia induced death of more than 50% mature neurons in the hippocampal CA1 field (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink