Prognostic role of homeostasis model assessment and oral glucose tolerance test in nondiabetic patients with Bell’s palsy
| Autor: | Tuğba Karagöz, Mustafa Sahin, Mehmet Hakan Korkmaz, Erman Cakal, Kemal Keseroğlu, Ali Özdek, Emel Çadalli Tatar, Ömer Bayır |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
medicine.medical_specialty HOMA-IR index prediabetes 030204 cardiovascular system & hematology Gastroenterology Article Impaired glucose tolerance Prediabetic State 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus insulin resistance Bell's palsy medicine Bell Palsy Homeostasis Humans Prediabetes 0303 health sciences Palsy 030306 microbiology business.industry Incidence (epidemiology) General Medicine Bell’s palsy Glucose Tolerance Test medicine.disease Prognosis Case-Control Studies business |
| Zdroj: | Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 1300-0144 |
| Popis: | Background/aim We aimed to revealthe incidence and predictive role of insulin resistance and distorted oral glucose tolerance test in nondiabetic patients withBell’s Palsy (BP). Materials and methods Eighty-sixpatients with BP and 28 control subjects; all with normal blood glucose levels and no history of diabetes, were enrolled in the study. We investigated insulin resistance (IR) in all subjects, in terms of HOMA-IR greater than 2.7. Sixty-two of the patients also underwent an oral glucose tolerance test (OGTT). Results The mean HOMA-IR value was significantly increased in patients, compared to the control group (3.2 vs 1.6; P < 0.01). IR was detected more in BP patients than in controls (P < 0.05). The patients with higher HOMA-IR values had more severe facial dysfunction at the initial presentation and complete recovery time took longer than the patients with normal HOMA-IR value (75 days vs 42 days; P < 0.05). Following a 2h-OGTT, impaired glucose tolerance and newly diagnosed DM were found in 60% of the patients. Recovery time was significantly longer in prediabetics and newly diagnosed diabetic patients than in patients with normal glycemia (68 days, 52 days, and 32 days, respectively; P < 0.01). Conclusion There is a strong linkage between HOMA-IR value and BP prognosis so HOMA-IR value may have a significant role of predicting BP prognosis at presentation. |
| Databáze: | OpenAIRE |
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