Effect of Local Hemostatics on Platelet Aggregation
| Autor: | H Holmsen, Einar Sudmann, O G Anfinsen, Eirik Solheim |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Epinephrine Platelet Aggregation Platelet aggregation Polyesters Bone wax Oxidized cellulose Palmitates In Vitro Techniques Hemostatics chemistry.chemical_compound Humans Platelet Platelet activation Local hemostatics Cellulose Chemistry In vitro Adenosine Diphosphate Drug Combinations Biochemistry Waxes Hemostasis Biophysics Gelatin Female Surgery Collagen |
| Zdroj: | European Surgical Research. 23:45-50 |
| ISSN: | 1421-9921 0014-312X |
| DOI: | 10.1159/000129135 |
| Popis: | The platelets play an important role in the normal hemostasis, and it is known that both natural and synthetic macromolecules may induce platelet activation and aggregation. Thus, the purpose of the present study was to investigate the platelet aggregating effect of five different local hemostatics. Platelet aggregation was assessed by aggregometry. Unwoven fleece of bovine collagen polymer in fibrillar form induced aggregation in combination with small amounts of platelet agonists; ADP and adrenaline. Ordinary, nonabsorbable bone wax also induced aggregation in combination with the agonists, but larger concentrations of agonists were needed. Bioerodible polyorthoester with physical properties such as bone wax, oxidized cellulose and gelatin sponge did not promote platelet aggregation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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