PD-L1 expression associated with Epstein-Barr virus status and patients survival in a large cohort of gastric cancer patients in northern Brazil
| Autor: | Jersey Heitor da Silva Maués, Rommel Mario Rodriguez Burbano, Paulo Pimentel Assumpção, Igor Brasil Costa, Paulo Cardoso Soares, Claúdia Nazaré de Souza Almeida Titan Martins, Caroline de Fátima Aquino Moreira-Nunes, Isamu Komatsu Lima, Leticia Martins Lamarão, Carolina Rosal Teixeira de Souza, Danielle Feio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
PD-L1
0301 basic medicine Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment medicine.disease_cause Article Virus Epstein–Barr virus 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Prote?na 2 Ligante de Morte Celular Programada 1 RC254-282 Messenger RNA biology business.industry gastric cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Immunotherapy medicine.disease humanities 030104 developmental biology Neoplasias G?stricas 030220 oncology & carcinogenesis biology.protein biomarker Biomarker (medicine) Biomarcadores Tumorais Herpesvirus Humano 4 / patogenicidade business Gastric Neoplasm |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC Cancers, Vol 13, Iss 3107, p 3107 (2021) Cancers Volume 13 Issue 13 |
| Popis: | Gastric cancer (GC) is a worldwide health problem, making it one of the most common types of cancer, in fifth place of all tumor types, and the third highest cause of cancer deaths in the world. There is a subgroup of GC that consists of tumors infected with the Epstein–Barr virus (EBV) and is characterized mainly by the overexpression of programmed cell death protein-ligand-1 (PD-L1). In the present study, we present histopathological and survival data of a thousand GC patients, associated with EBV status and PD-L1 expression. Of the thousand tumors analyzed, 190 were EBV-positive and the vast majority (86.8%) had a high relative expression of mRNA and PD-L1 protein (p < 0.0001) in relation to non-neoplastic control. On the other hand, in EBV-negative samples, the majority had a low PD-L1 expression of RNA and protein (p < 0.0001). In the Kaplan–Meier analysis, the probability of survival and increased overall survival of EBV-positive GC patients was impacted by the PD-L1 overexpression (p < 0.0001 and p = 0.004, respectively). However, the PD-L1 low expression was correlated with low overall survival in those patients. Patients with GC positive for EBV, presenting PD-L1 overexpression can benefit from immunotherapy treatments and performing the quantification of PD-L1 in gastric neoplasms should be adopted as routine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|