Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women
| Autor: | Anne-Mette Hvas, Anne L. Morkbak, Eva Greibe, Dorte L Lildballe, Ebba Nexo, Birgitte Horst Andreasen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Haptocorrin Homocysteine Denmark Clinical Biochemistry Methylmalonic acid Cobalamin chemistry.chemical_compound Transcobalamin Pregnancy Internal medicine hemic and lymphatic diseases medicine polycyclic compounds Humans heterocyclic compounds Cyanocobalamin Vitamin B12 Longitudinal Studies Transcobalamins integumentary system business.industry Biochemistry (medical) nutritional and metabolic diseases General Medicine medicine.disease Vitamin B 12 Endocrinology chemistry Female Pregnancy Trimesters business Biomarkers Methylmalonic Acid |
| Zdroj: | Greibe, E, Andreasen, B H, Lildballe, D L, Morkbak, A L, Hvas, A-M & Nexø, E 2011, ' Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women ', Clinical Chemistry and Laboratory Medicine, vol. 49 . https://doi.org/10.1515/CCLM.2011.682 |
| Popis: | BACKGROUND Currently, it is unknown whether the decline in plasma cobalamin observed during pregnancy is caused by malabsorption of the vitamin. This study examined cobalamin absorption and markers of cobalamin status during normal pregnancy. METHODS Twenty-seven pregnant Danish women were examined at gestation weeks 13, 24 and 36. The absorption test CobaSorb was performed in all women implying measurement of holotranscobalamin or cyanocobalamin bound to transcobalamin before and after 2 days intake of 3 × 9 μg cobalamin. Serum cobalamin and the two cobalamin binding proteins transcobalamin and haptocorrin, including haptocorrin saturated with cobalamin or analogues, were measured, and so was plasma methylmalonic acid and homocysteine. RESULTS No change in the uptake of cobalamin was observed throughout pregnancy. Serum cobalamin displayed a gradual decline during pregnancy (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|