Human physiological and metabolic responses to an attempted winter crossing of Antarctica: the effects of prolonged hypobaric hypoxia
| Autor: | Alex Kumar, Robert J Lambert, Katie A. O'Brien, Mike Stroud, Ana Anton-Solanas, Lindsay M. Edwards, Ross D. Pollock, S Harridge, Robert Andrew Atkinson, David A. Green |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine Physiology Acclimatization Antarctic Regions Adipose tissue chronic exposure Altitude Sickness Incremental exercise 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Physiology (medical) Metabolism and Regulation medicine Humans Hypoxia Exercise Respiratory exchange ratio Altitude sickness Adiposity Original Research Bone mineral Pulmonary Gas Exchange business.industry Altitude Fatty Acids Middle Aged Hypoxia (medical) hypobaric hypoxia medicine.disease Cold Temperature 030104 developmental biology Expeditions Lean body mass medicine.symptom business 030217 neurology & neurosurgery Extreme Environments |
| Zdroj: | Physiological Reports O'Brien, K A, Pollock, R D, Stroud, M, Lambert, R J, Kumar, A, Atkinson, R A, Green, D A, Anton-Solanas, A, Edwards, L M & Harridge, S D R 2018, ' Human physiological and metabolic responses to an attempted winter crossing of Antarctica : the effects of prolonged hypobaric hypoxia ', Physiology Reports, vol. 6, no. 5 . https://doi.org/10.14814/phy2.13613 |
| ISSN: | 2051-817X |
| DOI: | 10.14814/phy2.13613 |
| Popis: | An insufficient supply of oxygen to the tissues (hypoxia), as is experienced upon high-altitude exposure, elicits physiological acclimatization mechanisms alongside metabolic remodeling. Details of the integrative adaptive processes in response to chronic hypobaric hypoxic exposure remain to be sufficiently investigated. In this small applied field study, subjects (n = 5, male, age 28-54 years) undertook a 40 week Antarctica expedition in the winter months, which included 24 weeks residing above 2500 m. Measurements taken pre- and postexpedition revealed alterations to glucose and fatty acid resonances within the serum metabolic profile, a 7.8 (±3.6)% increase in respiratory exchange ratio measured during incremental exercise (area under curve, P > 0.01, mean ± SD) and a 2.1(±0.8) % decrease in fat tissue (P < 0.05) postexpedition. This was accompanied by an 11.6 (±1.9) % increase (P > 0.001) in VO2max corrected to % lean mass postexpedition. In addition, spine bone mineral density and lung function measures were identified as novel parameters of interest. This study provides, an in-depth characterization of the responses to chronic hypobaric hypoxic exposure in one of the most hostile environments on Earth. |
| Databáze: | OpenAIRE |
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