Nephrogenic rests in Wilms tumors treated with preoperative chemotherapy: The UK SIOP Wilms Tumor 2001 Trial experience
| Autor: | Neil J. Sebire, Richard D. Williams, Kathy Pritchard-Jones, John R. Apps, Federica Ceroni, Gordan M. Vujanic, Veronica Moroz |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antineoplastic Agents Wilms Tumor Perilobar nephrogenic rest 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Preoperative Care medicine Prevalence Humans Pathological Nephrogenic rest Nephroblastomatosis Neoplasm Staging Hematology business.industry International Agencies Wilms' tumor medicine.disease Prognosis humanities Kidney Neoplasms United Kingdom Surgery 030104 developmental biology Intralobar Nephrogenic Rest Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Radiology business Follow-Up Studies |
| Zdroj: | Pediatric bloodcancer. 64(11) |
| ISSN: | 1545-5017 |
| Popis: | BACKGROUND: Nephrogenic rests (NRs) are abnormally persistent foci of embryonal cells, thought to be the precursor lesion of Wilms tumors (WTs). To date, their presence has not been systematically examined in WTs treated with preoperative chemotherapy. METHODS: A systematic analysis of the data on NRs in WTs treated with preoperative chemotherapy obtained from the UK cohort of the International Society of Pediatric Oncology (SIOP) WT 2001 Trial. The study was based on central pathology review of full sets of slides from pathological specimens, with a median of 28 slides reviewed per case. RESULTS: NRs were identified in 40% of unilateral WTs, including 25% perilobar nephrogenic rest (PLNR), 9% intralobar nephrogenic rest (ILNR), 5% both PLNR and ILNR, and 1% nephroblastomatosis, and in 93% of cases with bilateral lesions. ILNRs were associated with stromal histology and a younger age at diagnosis and found frequently in patients with congenital anomalies associated with WT1 mutation. PLNRs were found frequently in patients with overgrowth syndromes. CONCLUSIONS: The prevalence of NRs in WTs after preoperative chemotherapy observed in SIOP UK WT 2001 Trial is similar to the previously published data on NRs not treated with preoperative chemotherapy. Their epidemiology supports at least two pathways to Wilms tumorigenesis. |
| Databáze: | OpenAIRE |
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