Adventitial inflammation: a possible pathogenic link to the instability of atherosclerotic plaque
| Autor: | Cheng Lin Hu, Ji Zhou Xiang, Cong Xin Huang, Fei Fei Hu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Leukotrienes Inflammation Coronary Artery Disease Histamine Release Lesion chemistry.chemical_compound Adventitia Internal medicine Medicine Humans cardiovascular diseases Myocardial infarction Lymphocytes Mast Cells Arteritis business.industry Models Cardiovascular General Medicine Chlamydophila pneumoniae medicine.disease Coronary Vessels Coronary arteries medicine.anatomical_structure Atheroma chemistry Connective Tissue cardiovascular system Cardiology medicine.symptom business Histamine Artery |
| Zdroj: | Medical hypotheses. 68(6) |
| ISSN: | 0306-9877 |
| Popis: | A variety of cells, including fibroblasts, mast cells, macrophages, and ganglionic cells, are present in coronary artery adventitia. In the infarct-related coronary arteries of myocardial infarction patients, the majority of mast cells are found in the outer layer of the adventitia. Neurogenic stimulation of mast cells in the adventitia of coronary arteries may release vasoactive compounds, such as histamine and leukotrienes, which can contribute to the complex neurohormonal response that leads to abnormal coronary vasoconstriction. Lymphocytes and bacteria are also present mainly in the adventitial layer. Chlamydia pneumoniae is directly involved in the development of adventitial and plaque inflammation (pan-arteritis), leading to plaque rupture. Adventitial O(2)(-) may also play an extensive role in the control of vascular tone. Therefore, adventitial inflammation may play a pivotal role for atherosclerotic lesion development and atheroma instability. |
| Databáze: | OpenAIRE |
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