A promising hypothesis of c-KIT methylation/ expression paradox in c-KIT (+) squamous cell carcinoma of uterine cervix ----- CTCF transcriptional repressor regulates c-KIT proto-oncogene expression
| Autor: | Alexandra Ruan, Po-Hui Wang, Shih-Wen Chang, Jau-Chen Lin, Chih-Ping Han, Wan-Ru Chao |
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| Rok vydání: | 2015 |
| Předmět: |
Histology
Uterine Cervical Neoplasms Repressor Biology Proto-Oncogene Mas Epigenesis Genetic Pathology and Forensic Medicine c-KIT proto-oncogene Animals Humans Epigenetics Regulation of gene expression Squamous cell carcinoma of uterine cervix General Medicine Methylation Hypothesis DNA Methylation Molecular biology Gene Expression Regulation Neoplastic Proto-Oncogene Proteins c-kit CpG site CTCF DNA methylation Carcinoma Squamous Cell Cancer research CTCF repressor Female |
| Zdroj: | Diagnostic Pathology |
| ISSN: | 1746-1596 |
| DOI: | 10.1186/s13000-015-0438-2 |
| Popis: | We recently reported one interesting case showing mutation-free c-KIT proto-oncogene overexpression and paradoxical hypermethylation in 54 cases of primary squamous cell carcinoma of uterine cervix (SCC). However, its molecular mechanisms still remain unknown. We propose the hypothesis that increased methylation at the CpG islands on the promoter near the first exon region might interfere with the binding of CTCF repressor with c-KIT promoter that regulates c-KIT proto-oncogene expression in such case. Further studies focusing on the status of epigenetic modifications of mutation-free c-KIT (+) tumors are encouraged. |
| Databáze: | OpenAIRE |
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