Alterations in lipoprotein pattern in liver plasma membranes from rats of different ages
| Autor: | Vladimir P. Skipski, Marion Barclay, Olga Terebus-Kekish |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
medicine.medical_specialty Aging Liver cytology Sonication ATPase Lipoproteins Biology Nucleotidases Internal medicine Parenchyma medicine Animals chemistry.chemical_classification Adenosine Triphosphatases Cell Membrane Rats Membrane Enzyme Endocrinology Membrane protein chemistry Biochemistry Liver Solubility biology.protein Lipoprotein pattern Lipoproteins HDL Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 1:357-365 |
| ISSN: | 0047-6374 |
| Popis: | Increasing age in the male rat results in changes in the plasma membranes of the parenchymal cells of liver. The extrinsic protein, soluble in 0.15 M NaCl, increases, and the specific activities of the membrane-localized enzymes are decreased: that for 5′-nucleotidase not until at least 88 weeks of age, when it decreases to about one-half; and that for ATPase after 19 weeks of age, with a decrease of over one-half. The remainder of the membrane protein, the intrinsic, or protein quite insoluble in more physiologic aqueous media, is composed of at least three lipoproteins “solubilized” by mild sonication and separated by density gradients. The least dense, A, (d |
| Databáze: | OpenAIRE |
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