| Autor: |
Tatsuya, Higashi, Saki, Aso, Hiroaki, Horisaki, Takenori, Ito, Sakurako, Tanaka, Shoichi, Nishimoto-Kusunose, Shoujiro, Ogawa, Kazuhiko, Kato, Hisamitsu, Ide |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Clinica Chimica Acta. 538:157-163 |
| ISSN: |
0009-8981 |
| DOI: |
10.1016/j.cca.2022.11.019 |
| Popis: |
The chronic abnormal production of testosterone (T) is associated with many disorders in men. Fingernail clippings might be more suited for the diagnosis and medium-to-long term therapeutic monitoring for the T-related chronic disorders than the blood-derived specimens. The objective of this study was to characterize a thumbnail clipping as the specimen for assessing the several months-old T status.Thumbnail clippings from various subjects were analyzed by liquid chromatography/electrospray ionization-tandem mass spectrometry to evaluate the gender difference, and changes caused by aging and androgen deprivation therapy (ADT) in the thumbnail T concentration.There was an evident gender difference in the thumbnail T concentrations [male; 2.55 ± 0.85 ng/g and female; 0.48 ± 0.29 ng/g, mean ± SD (n = 25 each), Welch t-test]. The thumbnail T concentrations significantly decreased with age in men (n = 268, Scheffé F-test), which was similar to those of the free or bioavailable T in serum/plasma. The thumbnail T concentrations sharply decreased by a 6-months ADT (especially the effect of the luteinizing hormone-releasing hormone agonist/antagonist) for patients with prostate cancer (n = 10).The thumbnail clipping can be a specimen to retrospectively assess the average T production. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect