Risk Factors for Posttransplant Erythrocytosis: Parathyroid Hormone Paradox?
| Autor: | Ulver Derici, Ekin Yesiloglu, Omer Faruk Akcay, Musa Bali, Farabi Fettahoglu, Berfu Korucu, Hasan Haci Yeter |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Transplantation
Creatinine medicine.medical_specialty Univariate analysis business.industry medicine.medical_treatment Renal function Parathyroid hormone Odds ratio Gastroenterology Peritoneal dialysis chemistry.chemical_compound chemistry Internal medicine Medicine Renal replacement therapy business Dialysis |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. |
| ISSN: | 2146-8427 |
| Popis: | Objectives Posttransplant erythrocytosis affects 8% to 26% of kidney transplant recipients. In this study, our aim was to define associations among hypercalcemia, persistent hyperparathyroidism, and posttransplant erythrocytosis. We also investigated the effects of biologic sex, age, and dialysis modality before transplant on posttransplant erythrocytosis development. Materials and methods We enrolled 247 patients [159 (64%) male and 88 (36%) female] who underwent kidney transplant between 2009 and 2018. All demographic and laboratory parameters were retrospectively analyzed as possible factors associated with posttransplant erythrocytosis. Results Fifty-nine (24%) of total patients had posttransplant erythrocytosis. The median time to posttransplant erythrocytosis development was 16 months (range, 8-34 mo). Male sex, the use of peritoneal dialysis as maintenance renal replacement therapy before kidney transplant, and persistent hyperparathyroidism were defined as independent risk factors for posttransplant erythrocytosis development in our multivariate logistic regression analyses (odds ratio = 5.228, 3.963, and 4.109, respectively). In addition, high serum creatinine levels were associated with a lower incidence of posttransplant erythrocytosis (odds ratio = 0.253). Although significance did not remain after multivariate analysis, hypercalcemia was found to be significantly associated with posttransplant erythrocytosis in univariate analyses (odds ratio = 1.768). In subgroup analyses, where only male patients were evaluated, persistent hyperparathyroidism and peritoneal dialysis were found to be independent risk factors for posttransplant erythrocytosis development (odds ratio = 4.176 and 5.003). Conclusions Persistent hyperparathyroidism and hypercalcemia could precipitate development of posttransplant erythrocytosis. The preserved residue renal function may be associated with increased endogenous erythropoietin, which could lead to posttransplant erythrocytosis development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|