Studies on the adrenal cortex of hypophysectomized rats: A model for abnormal cellular atrophy and death
| Autor: | Tuan H. Kuo, Victoria H. Drzewiecki, T. T. Tchen, Samuel W. Chan, K. M. Mostafapour |
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| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Hypophysectomy Lysis Clinical chemistry medicine.medical_treatment Clinical Biochemistry In Vitro Techniques Biology Endoplasmic Reticulum Atrophy Adrenocorticotropic Hormone Internal medicine Adrenal Glands medicine Protein biosynthesis Animals RNA Messenger Molecular Biology Adrenal cortex Cell Membrane DNA Cell Biology General Medicine medicine.disease Mitochondria Rats medicine.anatomical_structure Endocrinology Adrenal Cortex Dactinomycin Ultrastructure Corticosterone |
| Zdroj: | Molecular and Cellular Biochemistry. 15:79-87 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/bf01793330 |
| Popis: | Biochemical and ultrastructural studies indicate that the atrophy of adrenal cortex in hypoyhysectomized rats involves the following changes: (1) One to two days after hypophysectomy, there is loss of "template activity" resulting from cumulative DNA-damage and heterochromatinization. In vivo ACTH-administration led to recuperation of these cells, indicating damage during hypophysectomized state to be reversible. (2) If the duration of hypophysectomy is prolonged, some of the cells become irreversibly damaged and can no longer recuperate after in vivo ACTH administration. (3) The period of most rapid cell death is from the third to seventh day after hypophysectomy. The cause of cell death is probably due to membrane damage in the absence of protein synthesis, leading to lysis of the cells. Lysozomes and macrophages are apparently not involved. |
| Databáze: | OpenAIRE |
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