Mammalian Metallothionein-2A and Oxidative Stress
| Autor: | Xue-Bin Ling, Hong-Wei Wei, Yu-You Wu, Jun Wang, Tian-Fa Li, Yue-Qiong Kong, Junli Guo, Ji-ke Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
MAP Kinase Signaling System Review Biology medicine.disease_cause Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Mediator Neoplasms Detoxification medicine Animals Humans Metallothionein oxidative stress Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy chemistry.chemical_classification reactive oxygen species Reactive oxygen species Mechanism (biology) Kinase Organic Chemistry metallothionein-2A General Medicine Computer Science Applications Cell biology 030104 developmental biology Biochemistry chemistry lcsh:Biology (General) lcsh:QD1-999 Cardiovascular Diseases mitogen-activated protein kinases Second messenger system Nervous System Diseases Oxidative stress |
| Zdroj: | International Journal of Molecular Sciences, Vol 17, Iss 9, p 1483 (2016) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation. For many years, most studies evaluating the effects of MT2A have focused on reactive oxygen species (ROS), as second messengers that lead to oxidative stress injury of cells and tissues. Recent studies have highlighted that oxidative stress could activate mitogen-activated protein kinases (MAPKs), and MT2A, as a mediator of MAPKs, to regulate the pathogenesis of various diseases. However, the molecule mechanism of MT2A remains elusive. A deeper understanding of the functional, biochemical and molecular characteristics of MT2A would be identified, in order to bring new opportunities for oxidative stress therapy. |
| Databáze: | OpenAIRE |
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