Chromosome aberrations of human small cell lung cancer induced by a new111in-bleomycin complex
| Autor: | Yosh Maruyama, De-Yan Hou, Joseph R. Drago |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Pathology Lung Neoplasms Chromatids Biology Bleomycin chemistry.chemical_compound Glioma Tumor Cells Cultured medicine Humans Carcinoma Small Cell Chromosome Aberrations Lung Colcemid Indium Radioisotopes Cytogenetics Chromosome Cancer General Medicine medicine.disease Combined Modality Therapy respiratory tract diseases medicine.anatomical_structure Oncology chemistry Cancer cell Cancer research Surgery |
| Zdroj: | Journal of Surgical Oncology. 51:236-242 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930510407 |
| Popis: | A new 111Indium labeled bleomycin complex (111In-BLMC) was prepared and found to be effective for tumor imaging and therapy both in mouse glioma and human small cell lung cancer (SCLC) cells. Chromosome aberrations were studied in human SCLC cells to explore its mechanisms of killing cancer cells. SCLC cells (N417) were exposed to 111In-BLMC, BLM, or 111InCl3 (for control) for 1 hour, treated with colcemid, and chromosomal changes were analyzed. A dramatic increase in chromatic gaps, breaks, chromosome breaks, double minutes, rings, triradii, quadriradii, and chromosome stickiness were observed in the cells treated by 111In-BLMC compared to BLM or 111InCl3. These results indicated that 111In-BLMC has therapeutic potential for combination chemo-radiotherapy of cancer (e.g., by Auger electrons and local energy deposition). © 1992 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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