Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging

Autor:	Andrew S. Weyrich, Bhanu Kanth Manne, Mark A. Supiano, Zechariah Franks, Jesse W. Rowley, Anish Bhatnagar, Matthew T. Rondina, Robert A. Campbell, Hansjörg Schwertz
Rok vydání:	2018
Předmět:	Blood Platelets Male 0301 basic medicine Aging Immunology Inflammation Granzymes Monocytes Article Proinflammatory cytokine Transcriptome 03 medical and health sciences medicine Humans Immunology and Allergy Platelet Cells Cultured Chemokine CCL2 Aged Serine protease Regulation of gene expression biology Interleukin-8 High-Throughput Nucleotide Sequencing Middle Aged Toll-Like Receptor 4 030104 developmental biology Gene Expression Regulation biology.protein Granzyme A TLR4 Cytokines Female Inflammation Mediators medicine.symptom
Zdroj:	The Journal of Immunology. 200:295-304
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.1700885
Popis:	Dysregulated inflammation is implicated in the pathobiology of aging, yet platelet–leukocyte interactions and downstream cytokine synthesis in aging remains poorly understood. Platelets and monocytes were isolated from healthy younger (age
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da11ea9b94d8b416519ffa901f103169 https://doi.org/10.4049/jimmunol.1700885 Zobrazit plný text záznamu