Choking deaths: the role of antipsychotic medication
| Autor: | Stephen Cordner, David Ruschena, Cameron Wallace, Simon Palmer, Paul E. Mullen, Philip Burgess, Justin Barry-Walsh, Olaf H. Drummer |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis medicine.drug_class medicine.medical_treatment Neurocognitive Disorders Thioridazine Lithium Sudden death 03 medical and health sciences Age Distribution 0302 clinical medicine Risk Factors Organic mental disorders medicine Humans 030212 general & internal medicine Sex Distribution Antipsychotic Psychiatry Aged Asphyxia Mood stabilizer Middle Aged medicine.disease 030227 psychiatry Airway Obstruction Psychiatry and Mental health Psychotic Disorders Schizophrenia Drug Therapy Combination Female medicine.symptom Psychology Choking Antipsychotic Agents medicine.drug |
| Zdroj: | Monash University |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.183.5.446 |
| Popis: | BackgroundAn increased risk of choking associated with antipsychotic medication has been repeatedly postulated.AimsTo examine this association in a large number of cases of choking deaths.MethodCases of individuals who had died because of choking were linked with a case register recording contacts with public mental health services. The actual and expected rates of psychiatric disorder and the presence of psychotropic medication in post-mortem blood samples were compared.ResultsThe 70 people who had choked to death were over 20 times more likely to have been treated previously for schizophrenia. They were also more likely to have had a prior organic psychiatric syndrome. The risk for those receiving thioridazine or lithium was, respectively, 92 times and 30 times greater than expected. Other antipsychotic and psychotropic drugs were not over-represented.ConclusionsThe increased risk of death in people with schizophrenia may be a combination of inherent predispositions and the use of specific antipsychotic drugs. The increased risk of choking in those with organic psychiatric syndromes is consistent with the consequences of compromised neurological competence. |
| Databáze: | OpenAIRE |
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