Increased incidence and size of cavum septum pellucidum in children with chromosome 22q11.2 deletion syndrome
| Autor: | Vy Nguyen, Joseph D. Pinter, Tony J. Simon, Yufeng Qin, Joel T. Johnson, Elliott A. Beaton |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Chromosomes Human Pair 22 Neuroscience (miscellaneous) Brain mapping Article DiGeorge syndrome parasitic diseases DiGeorge Syndrome medicine Humans Radiology Nuclear Medicine and imaging Child Septum pellucidum Analysis of Variance Brain Mapping medicine.diagnostic_test Incidence Incidence (epidemiology) Genetic disorder Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Female Septum Pellucidum Psychology Cavum septum pellucidum Cavum vergae |
| Zdroj: | Psychiatry Research: Neuroimaging. 181:108-113 |
| ISSN: | 0925-4927 |
| Popis: | Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a result of a hemizygotic microdeletion that results in a variety of impairments in children including greater risk for psychiatric ailments in adulthood. We used high-resolution magnetic resonance imaging to accurately quantify the length and, for the first time, volume, of the cavum septum pellucidum (CSP) in children aged 7 to 14 years with 22q11.2DS and typically developing (TD) controls. Significantly greater anteroposterior length and greater CSP volumes were found in children with 22q11.2DS compared with controls. Furthermore, the largest CSP were found only in the 22q11.2DS group and with a much higher incidence than previously reported in the literature. Given the significant midline anomalies in the brains of those affected by 22q11.2DS, large CSP may be a biomarker of atypical brain development. The implication of these larger CSP for cognitive and behavioral development is a topic in need of further investigation. |
| Databáze: | OpenAIRE |
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