Novel bioresorbable tricalcium phosphate/polyhydroxyoctanoate (TCP/PHO) composites as scaffolds for bone tissue engineering applications
| Autor: | Andrzej Wróbel, Aneta Zima, Bartosz Leszczyński, Tomasz Witko, Katarzyna Haraźna, Maciej Guzik, Anna Ślósarczyk, Małgorzata Zimowska, Ewelina Cichoń, Malgorzata Witko, Szymon Skibiński |
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| Rok vydání: | 2019 |
| Předmět: |
Calcium Phosphates
Materials science Composite number Biomedical Engineering Biocompatible Materials 02 engineering and technology Bioceramic engineering.material Bone and Bones Bone tissue engineering Biomaterials 03 medical and health sciences 0302 clinical medicine Coating Biomimetics Ceramic Composite material chemistry.chemical_classification Tissue Engineering Tissue Scaffolds 030206 dentistry Polymer 021001 nanoscience & nanotechnology chemistry Mechanics of Materials visual_art Wettability engineering visual_art.visual_art_medium Biopolymer 0210 nano-technology Porosity Layer (electronics) |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 98:235-245 |
| ISSN: | 1751-6161 |
| DOI: | 10.1016/j.jmbbm.2019.06.028 |
| Popis: | Development of new composite materials for bone tissue engineering is a constantly growing field of medicine. Therefore there is a continuous need in creating novel materials that can not only regenerate the defected tissue but also nourish it while the healing process progresses. Here we present a novel type of composite material that fulfils these requirements. The study describes creation of a composite with macroporous bioceramic core that is infiltrated with a thin biopolymer layer. The ceramic component, namely tricalcium phosphate (TCP), due to its mechanistic and bioactive properties may promote new bone creation as shown through the in vitro studies. To the best of our knowledge the coating layer was created for the first time from a representative of bacterially derived medium chain length polyhydroxyalkanoate polymers (mcl-PHA), namely polyhydroxyoctanoate (PHO). This polymer layer not only profoundly changed the stress-strain characteristics of the bioceramic foam but also released ( R )-3-hydroxyacids and their dimers/trimers to the investigated environment. In the manuscript we have in depth characterised these materials employing a set of basic procedures, through 3D structure reconstruction and finishing with prolonged in vitro experiments. |
| Databáze: | OpenAIRE |
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