Precision medicine in the allergy clinic: the application of component resolved diagnosis

Autor:	Carmen Panaitescu, Laura Haidar, Maria Roxana Buzan, Manuela Grijincu, Daniela Elena Spanu, Catalina Cojanu, Alexandru Laculiceanu, Roxana Bumbacea, Ioana Agache
Rok vydání:	2022
Předmět:	Desensitization Immunologic Immunology Humans Immunology and Allergy Allergens Precision Medicine Rhinitis Allergic Food Hypersensitivity
Zdroj:	Expert Review of Clinical Immunology. 18:145-162
ISSN:	1744-8409 1744-666X
DOI:	10.1080/1744666x.2022.2034501
Popis:	A precise diagnosis is key for the optimal management of allergic diseases and asthma.Component-resolved diagnosis (CRD) has solved most of the limitations of extract-based diagnostic procedures and is currently valuable tool for the precision diagnosis in the allergy clinic, for venom and food allergy, asthma, allergic rhinitis, and atopic dermatitis. Its implementation in daily practice facilitates: a) the distinction between genuine multiple sensitizations and cross-reactive sensitization in polysensitized patients; b) the prediction of a severe, systemic reaction in food or insect venom allergy; c) the optimal selection of allergen immunotherapy based on the patient sensitization profile. This paper describes its main advantages and disadvantages, cost-effectiveness and future perspectives.The diagnostic strategy based on CRD is part of the new concept of precision immunology, which aims to improve the management of allergic diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0c46f3232f964677957639147911d3 https://doi.org/10.1080/1744666x.2022.2034501 Zobrazit plný text záznamu