The relation between paracetamol use and asthma: a GA2LEN European case-control study
| Autor: | S, Shaheen, J, Potts, L, Gnatiuc, J, Makowska, M L, Kowalski, G, Joos, T, van Zele, Y, van Durme, I, De Rudder, S, Wöhrl, J, Godnic-Cvar, L, Skadhauge, G, Thomsen, T, Zuberbier, K C, Bergmann, L, Heinzerling, M, Gjomarkaj, A, Bruno, E, Pace, S, Bonini, W, Fokkens, E J M, Weersink, C, Loureiro, A, Todo-Bom, C M, Villanueva, C, Sanjuas, J-P, Zock, C, Janson, P, Burney |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, Pulmonology |
| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Risk medicine.medical_specialty Allergy Population Pain Disease immune system diseases Internal medicine Epidemiology Odds Ratio Medicine Humans education Asthma Acetaminophen education.field_of_study Analgesics business.industry Confounding digestive oral and skin physiology Case-control study Middle Aged medicine.disease Surgery respiratory tract diseases Europe Treatment Outcome Case-Control Studies Female business medicine.drug |
| Zdroj: | European respiratory journal, 32(5), 1231-1236. European Respiratory Society Shaheen, S, Potts, J, Gnatiuc, L, Kowalski, M L, Joos, G, van Zele, T, van Durme, Y, De Rudder, I, Wöhrl, S, Godnic-Cvar, J, Skadhauge, L, Thomsen, G, Zuberbier, T, Bergmann, K C, Heinzerling, L, Gjomarkaj, M, Bruno, A, Pace, E, Bonini, S, Fokkens, W, Weersink, E J M, Loureiro, C, Villanueva, C M, Sanjuas, C, Zock, J-P, Janson, C & Burney, P 2008, ' The relation between paracetamol use and asthma : a GA2LEN European case-control study ', European Respiratory Journal . https://doi.org/10.1183/09031936.00039208 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00039208 |
| Popis: | Udgivelsesdato: Jun-25 Studies from the UK and the USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking.As part of a multi-centre case-control study organised by the GA(2)LEN network we have examined whether frequent paracetamol use is associated with adult asthma across Europe. The network compared 521 cases with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 507 controls with no diagnosis of asthma and no asthmatic symptoms in the last 12 months across 12 European centres. All cases and controls were selected from the same population defined by age (20-45 years) and place of residence.In a random effects meta-analysis, after controlling for confounders, the adjusted odds ratio for asthma associated with weekly use of paracetamol, compared with less frequent use, was 2.87 (95% CI: 1.49 to 5.37), P=0.002. There was no evidence for heterogeneity across centres. No association was seen between use of other analgesics and asthma.These data add to the increasing and consistent epidemiological evidence implicating frequent paracetamol use in asthma in diverse populations |
| Databáze: | OpenAIRE |
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