Evolution of the haemagglutinin-esterase gene of influenza C virus
Autor: | Fumio Kitame, Yasushi Muraki, Seiji Hongo, Kanetsu Sugawara, Kiyoto Nakamura |
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Rok vydání: | 1996 |
Předmět: |
Influenzavirus C
Genes Viral Lineage (evolution) Molecular Sequence Data Hemagglutinins Viral Chick Embryo Biology Evolution Molecular Viral Proteins Virology Evolution of influenza Animals Humans Amino Acid Sequence Gene Peptide sequence Phylogeny Genetics Base Sequence Phylogenetic tree Maximum parsimony DNA Viral Influenza C Virus Chickens Viral Fusion Proteins |
Zdroj: | Journal of General Virology. 77:673-679 |
ISSN: | 1465-2099 0022-1317 1966-1983 |
Popis: | The nucleotide sequences of the haemagglutinin-esterase (HE) genes of 18 influenza C virus strains isolated in Japan during the period from 1964 to 1988 (11 published and 7 new sequences) were analysed to examine their evolutionary relationships. The phylogenetic tree constructed by the maximum parsimony method revealed the existence of four discrete lineages (I to IV), one of which (lineage III) may have died out in the late 1970s. Sequential evolution was demonstrated within seven strains of lineage I, which allowed estimation of an evolutionary rate of 0.49 x 10-3 nucleotide substitutions per site per year, a value corresponding to about one-ninth of the rates of human influenza A virus haemagglutinin genes. In the previously proposed immunodominant region on HE protein (positions 178 to 217), there was little or no amino acid sequence divergence among viruses on the same lineage although considerable divergence was seen among those on different lineages, raising the possibility that immune selection may not have played a significant role in the evolution of the glycoprotein, at least not after separation into lineages occurred. It was also found that the HE genes of the seven isolates obtained outside Japan during 1966-1983 could be each assigned to one of lineages I, II and IV, which suggests that influenza C virus is capable of spreading worldwide. |
Databáze: | OpenAIRE |
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