Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
| Autor: | Keita Ishiwari, Christopher P. King, Jordan A. Tripi, Leah C. Solberg Woods, Oksana Polesskaya, Aidan P. Horvath, Terry E. Robinson, Katie Holl, Shelly B. Flagel, Apurva S. Chitre, Paul J. Meyer, Abraham A. Palmer, Alesa R. Hughson, Alexander Lamparelli |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Conditioning Classical Food cue Developmental psychology Rats Sprague-Dawley Substance Misuse 0302 clinical medicine Cocaine Contextual conditioning media_common Multidisciplinary Behavior Animal Neuropsychology Preference Classical conditioning Large sample Incentive salience Cohort Medicine Female Cues Locomotion Science media_common.quotation_subject Large population Context (language use) Biology Basic Behavioral and Social Science Article 03 medical and health sciences Reward Behavioral and Social Science Animals Stock (geology) Behavior Motivation Animal Addiction Classical Brain Disorders Rats 030104 developmental biology Good Health and Well Being Food Sprague-Dawley Drug Abuse (NIDA only) 030217 neurology & neurosurgery Conditioning |
| Zdroj: | Scientific reports, vol 11, iss 1 Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) |
| Popis: | Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive salience to food cues, which, in turn, contributes to the maintenance of cocaine self-administration, and cue-induced relapse of drug-seeking. Whereas each of these traits has established links to drug use, the relatedness between the individual traits themselves has not been well characterized in preclinical models. To this end, the propensity to attribute incentive salience to a food cue was first assessed in two distinct cohorts of 2716 outbred heterogeneous stock rats (HS; formerly N:NIH). We then determined whether each cohort was associated with performance in one of two paradigms (cocaine conditioned cue preference and cocaine contextual conditioning). These measure the unconditioned locomotor effects of cocaine, as well as conditioned approach and the locomotor response to a cocaine-paired floor or context. There was large individual variability and sex differences among all traits, but they were largely independent of one another in both males and females. These findings suggest that these traits may contribute to drug-use via independent underlying neuropsychological processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|