Photodiagnosis and treatment of condyloma acuminatum using 5-aminolevulinic acid and homemade devices
| Autor: | Cristina Kurachi, Vanderlei Salvador Bagnato, Mardoqueu Martins da Costa, Wellington Lombardi, Elizeu da Silva Ribeiro, Orlando C. C. Guimarães, Natalia Mayumi Inada, Silvana Maria Quintana |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Treatment response Adolescent medicine.medical_treatment Biophysics Photodynamic therapy Dermatology chemistry.chemical_compound Young Adult Medicine Humans Pharmacology (medical) Human papillomavirus Subclinical infection Aged Photosensitizing Agents Protoporphyrin IX business.industry Aminolevulinic Acid NEOPLASIAS (DIAGNÓSTICO) Condyloma Acuminatum Middle Aged Surgery Clinical trial Oncology chemistry Photochemotherapy Condylomata Acuminata Fluence rate Female business Genital Diseases Female |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Summary Background: The objective of this study was to improve the feasibility of applying topic 5-aminolevulinic acid (ALA) in photodiagnosis (PD) and treatment of condyloma caused by human papillomavirus (HPV) using two homemade handheld devices and to discuss the photodynamic therapy (PDT) as a suitable alternative for each of the cases studied. Both, protoporphyrin IX production and photodegradation were analyzed, and the pain experienced during the illumination was correlated with the light intensities. Methods: A total of 40 women with different grades of lesions caused by HPV were chosen from patients of the School of Medicine of Ribeirao Preto (University of Sao Paulo) and of the Unit of Public Health of Araraquara, Sao Paulo. Results: We did not encounter any unexpected difficulties using our devices during the treatment. The existence of an easily observable reddish fluorescence with large intensity concentrated on the lesions is the clinical indication of the penetration and the selective concentration of protoporphyrin IX in the clinical and subclinical lesions rather than in the healthy tissue. The aesthetic results were much better than those obtained by conventional techniques as surgery or cryogenics, with no recurrence reported after two years of treatment. Conclusions: Our results are proof for the various advantages using ALA cream for the PD and PDT in many different cases of condyloma by HPV. This study will be continued to investigate the PpIX photobleaching and the irradiance and fluence rate to optimize conducting the clinical trials, to improve the devices and therefore increase the treatment response. |
| Databáze: | OpenAIRE |
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