Cervical Cancer in Ethiopia: The Effect of Adherence to Radiotherapy on Survival

Autor: Susanne Unverzagt, Dirk Vordermark, Assefa Mathewos, Christoph Thomssen, Matthias Begoihn, Tigeneh Wondemagegnehu, Eva Johanna Kantelhardt, Bekuretsion Yonas, Adamu Addissie, Ulrike Moelle, Abreha Aynalem, Ahmedin Jemal
Rok vydání: 2018
Předmět:
Zdroj: The Oncologist. 23:1024-1032
ISSN: 1549-490X
1083-7159
Popis: Background Discontinuation of radiotherapy (RT) for cervical cancer (CC) in sub-Saharan Africa is common because of patient- and health service-related reasons. This analysis describes toxicities and the effect of adherence on survival. Materials and Methods A total of 788 patients with CC (2008–2012) who received RT at Addis Ababa University Hospital were included. External beam RT without brachytherapy was performed according to local guidelines. We previously described survival and prognostic factors. Now we analyzed adherence and survival according to total doses received. Adjustment via multivariate cox regression analysis was done. Results One-year overall survival (OS) after radical RT (n = 180) for International Federation of Gynecology and Obstetrics (FIGO) stages IIA–IIIA was 89% for discontinuation ( Conclusion Patients who adhered to guideline-conforming RT had optimum survival. Better supportive care, brachytherapy to reduce toxicities, socioeconomic support, and additional radiation capacities could contribute to better adherence and survival. Implications for Practice This study presents the effect of adherence on survival of 788 patients with cervical cancer receiving external beam radiotherapy without brachytherapy in Ethiopia. Discontinuation of planned radiotherapy according to local guidelines considerably reduced survival for all International Federation of Gynecology and Obstetrics (FIGO) stages treated (hazard ratios were 1.3, 3.1, and 7.3 for FIGO stages IIA–IIIA and IIIB–IVA and the palliative approach, respectively). Early toxicity (5% grade 3) should be treated to improve adherence. Economic difficulties and machine breakdown should also be addressed to reduce discontinuation and improve survival.
Databáze: OpenAIRE
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