Bioscaffolds embedded with regulatory modules for cell growth and tissue formation: A review
| Autor: | Sun Yazhou, Huixing Shen, Haohao Ning, Shi Xiaoquan, Pengju Wang, Liu Haitao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Growth regulation
0206 medical engineering Cell Biomedical Engineering 02 engineering and technology Matrix (biology) Tissue Preparation Article law.invention Organ reconstruction Biomaterials Tissue engineering law Cell growth regulation lcsh:TA401-492 medicine Tissue formation Synergetic stimulation lcsh:QH301-705.5 3D bioprinting Cell growth Chemistry 021001 nanoscience & nanotechnology Bioscaffolds 020601 biomedical engineering Cell biology medicine.anatomical_structure lcsh:Biology (General) lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Biotechnology |
| Zdroj: | Bioactive Materials Bioactive Materials, Vol 6, Iss 5, Pp 1283-1307 (2021) |
| ISSN: | 2452-199X |
| Popis: | The demand for artificial organs has greatly increased because of various aging-associated diseases and the wide need for organ transplants. A recent trend in tissue engineering is the precise reconstruction of tissues by the growth of cells adhering to bioscaffolds, which are three-dimensional (3D) structures that guide tissue and organ formation. Bioscaffolds used to fabricate bionic tissues should be able to not only guide cell growth but also regulate cell behaviors. Common regulation methods include biophysical and biochemical stimulations. Biophysical stimulation cues include matrix hardness, external stress and strain, surface topology, and electromagnetic field and concentration, whereas biochemical stimulation cues include growth factors, proteins, kinases, and magnetic nanoparticles. This review discusses bioink preparation, 3D bioprinting (including extrusion-based, inkjet, and ultraviolet-assisted 3D bioprinting), and regulation of cell behaviors. In particular, it provides an overview of state-of-the-art methods and devices for regulating cell growth and tissue formation and the effects of biophysical and biochemical stimulations on cell behaviors. In addition, the fabrication of bioscaffolds embedded with regulatory modules for biomimetic tissue preparation is explained. Finally, challenges in cell growth regulation and future research directions are presented. Graphical abstract The functions of different simulations on cells, including biophysical simulations and biochemical simulations are expounded. The regulatory methods for cell growth and tissue formation are organized mainly by three points, bioinks, 3D bioprinting methods, the effects of different simulations on cell behavior regulation. Also, the limitation of biological printing and regulation process and future research matters, are pointed out. We envisage this approach will offer an effective way to tissue reconstruction.Image 1 Highlights • The state of the art on scaffolds in regulating cell behaviors is reviewed. • The functions of different stimulations on cells are expounded. • The limitation of regulatory techniques and future directions, are presented. • The method of synergetic regulation for cell behaviors, are proposed. |
| Databáze: | OpenAIRE |
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