A large proportion of mediastinal and perirenal visceral fat of Siberian adult people is formed by UCP1 immunoreactive multilocular and paucilocular adipocytes
| Autor: | Angelica Di Vincenzo, Evgeny Isakov, Wiebe Venema, Martina Senzacqua, Maria Cristina Zingaretti, Antonio Giordano, Mikhail Thomski, Agrafena Efremova, Marina Protasoni, Saverio Cinti |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adrenergic Neurons Adult Male medicine.medical_specialty Physiology Adipose tissue 030209 endocrinology & metabolism Biology Intra-Abdominal Fat Human brown adipocytes Biochemistry Adipose capsule of kidney 03 medical and health sciences Young Adult 0302 clinical medicine Adipose Tissue Brown Internal medicine Parenchyma Brown adipose tissue medicine Humans Noradrenergic nerves Visceral fat Uncoupling Protein 1 Tyrosine hydroxylase General Medicine Middle Aged medicine.disease Obesity Thermogenin Cold Temperature Siberia Paucilocular adipocytes Uncoupling protein 1 Visceral adipose tissue 030104 developmental biology medicine.anatomical_structure Endocrinology Cell Transdifferentiation Female |
| Zdroj: | Journal of physiology and biochemistry. 76(2) |
| ISSN: | 1877-8755 |
| Popis: | Many deleterious consequences for health of excessive fat accumulation are due to visceral fat. Browning of visceral fat is mainly cold dependent and has been proposed as a possible tool for future therapies of obesity and related disorders. In this paper, we studied the composition of mediastinal and perirenal visceral fat, collected at necropsy, of human adults that lived in Siberia, one of the coldest regions of the earth. Data showed that a consistent part of the mediastinal and perirenal fat (up to about 40%) had the morphology typical of brown adipocytes and that a relevant percentage of them (up to about 30%) also expressed the functional marker uncoupling protein 1 (UCP1). Patients living mainly outdoor had higher percentage of brown-like adipocytes with more intensely UCP1 immunoreactive cells. The presence of numerous UCP1 immunoreactive paucilocular cells, a transitional stage of transdifferentiating adipocytes, supports the idea that visceral fat can be converted to brown adipose tissue in adult humans in physiological conditions. Tyrosine hydroxylase immunoreactive noradrenergic parenchymal nerve fibers were positively correlated to the number of multilocular adipocytes in mediastinal fat, and a similar trend was also observed in the perirenal fat. |
| Databáze: | OpenAIRE |
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