Controlled release of cortisone drugs from block copolymers synthetized by ATRP
| Autor: | Stefania Perna, S. La Carta, Giovanni Mazzotti, Loris Giorgini, Marco Rapisarda, D. Carbone, R. Di Gesù, Paola Rizzarelli, Graziella Valenti, G. Recca |
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| Přispěvatelé: | D'Amore A.,Grassia L.,Acierno D., Valenti, G, La Carta, S., Mazzotti, G., Rapisarda, M., Perna, S., Di Gesù, R., Giorgini, L., Carbone, D., Recca, G., Rizzarelli, P. |
| Rok vydání: | 2016 |
| Předmět: |
Drug
Biocompatibility business.industry media_common.quotation_subject block copolymer Pharmacology medicine.disease Bioinformatics Controlled release Disease control atom transfer radical polymerization block copolymers drug delivery systems Therapeutic approach poly(methyl methacrylate)-b-poly(hydroxyethyl methacrylate) Drug delivery medicine drug delivery system business betamethasone 17 21-dipropionate Macular edema Acrylic polymer media_common |
| Zdroj: | New York, N.Y.: American Institute of Physics, 2016 info:cnr-pdr/source/autori:Valenti, G.; La Carta, S.; Mazzotti, G.; Rapisarda, M.; Perna, S.; Di Gesu, R.; Giorgini, L.; Carbone, D.; Recca, G.; Rizzarelli, P./titolo:Controlled Release Of Cortisone Drugs From Block Copolymers Synthetized By ATRP/editore: /anno:2016 |
| ISSN: | 0094-243X |
| DOI: | 10.1063/1.4949681 |
| Popis: | Diseases affecting posterior eye segment, like macular edema, infection and neovascularization, may cause visual impairment. Traditional treatments, such as steroidal-drugs intravitreal injections, involve chronic course of therapy usually over a period of years. Moreover, they can require frequent administrations of drug in order to have an adequately disease control. This dramatically reduce patient's compliance. Efforts have been made to develop implantable devices that offer an alternative therapeutic approach to bypass many challenges of conventional type of therapy. Implantable drug delivery systems (DDS) have been developed to optimize therapeutic properties of drugs and ensure their slow release in the specific site. Polymeric materials can play an essential role in modulating drug delivery and their use in such field has become indispensable. During last decades, acrylic polymers have obtained growing interest. Biocompatibility and chemical properties make them extremely versatile, allowing their use in many field such as biomedical. In particular, block methacrylate copolymer with a balance of hydrophilic and hydrophobic properties can be suitable for prolonged DDS in biomedical devices. In this work, we focused on the realization of a system for controlled and long term release of betamethasone 17,21-dipropionate (BDP), a cortisone drug, from methacrylic block copolymers, to be tested in the treatment of the posterior eye's diseases. Different series of methyl methacrylate/hydroxyethyl methacrylate (MMA/HEMA) block and random copolymers, with different monomer compositions (10-60% HEMA), were synthetized by Atom Transfer Radical Polymerization (ATRP) to find the best hydrophilic/hydrophobic ratio, able to ensure optimal kinetic release. Copolymer samples were characterized by NMR spectroscopy (1H-NMR, 13C-NMR, CosY), SEC, TGA and DSC. Monitoring of drug release from films loaded with BDP was carried out by HPLC analysis. Evaluation of different kinetic models allowed to deduce that release of BDP is controlled over time from PMMA-b-PHEMA 53/47. In particular, PMMA-b-PHEMA 53/47 showed the best release profile to achieve the therapeutic reference dose of 3 μg/die, employed in treatment of posterior eye disease, up to four months. Accordingly, PMMA-b-PHEMA 53/47 has been tested to prepare ocular inserts. Ocular inserts with different shape and the same area of polymer films have been obtained using silicon moulds made by a 3D printer. |
| Databáze: | OpenAIRE |
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