Fibrinolytic Deficit and Platelet Activation in Atrial Fibrillation and Their Postablation Modulation
| Autor: | Debra Hoppensteadt, Mushabar Syed, Sallu Jabati, Stephen Statz, Timothy Rowe, Jawed Fareed, Abigail Otto, Amanda Walborn, Jeffrey Liles |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Time Factors medicine.medical_treatment CD40 Ligand Catheter ablation 030204 cardiovascular system & hematology ablation Pathogenesis 03 medical and health sciences chemistry.chemical_compound fibrinolytic deficit 0302 clinical medicine Internal medicine Atrial Fibrillation Plasminogen Activator Inhibitor 1 Fibrinolysis medicine Humans Prospective Studies Platelet activation Prospective cohort study platelet Inflammation business.industry Atrial fibrillation Original Articles Hematology General Medicine Middle Aged Platelet Activation Ablation medicine.disease 030104 developmental biology chemistry Case-Control Studies Plasminogen activator inhibitor-1 AFib Catheter Ablation Cardiology Female business Biomarkers |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis |
| ISSN: | 1938-2723 1076-0296 |
| DOI: | 10.1177/1076029617750270 |
| Popis: | This study aims to examine the effects of atrial fibrillation (AF) on the expression of the cellular mediators plasminogen activator inhibitor 1 (PAI-1) and CD40 ligand (CD40-L). Additionally, the effect of catheter ablation on the levels of the aforementioned biomarkers was also examined. In this prospective study, plasma samples were collected from patients with AF at baseline prior to ablation and at 1 and 3 months postablation. There was a statistically significant increase in CD40-L at baseline in patients with AF compared to control ( P = .0034). There was a statistically significant decrease in CD40-L levels postablation at both 1 month ( P < .0001) and 3 months ( P < .0001) compared to baseline. Baseline levels of PAI-1 were elevated compared to the control group (mean 19.55 ± 2.17 ng/mL vs 4.85 ± 0.41 ng/mL) and a statistically significant decrease in circulating PAI-1 levels 1 month postablation ( P = .05) was noted compared to preablation levels. These data suggest that inflammation plays an important role in the pathogenesis of AF and that these cellular mediators are modulated by catheter ablation. |
| Databáze: | OpenAIRE |
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