Fast co‐evolution of anti‐silencing systems shapes the invasiveness of Mu‐like DNA transposons in eudicots

Autor: Taku Sasaki, Kyudo Ro, Erwann Caillieux, Riku Manabe, Grégoire Bohl‐Viallefond, Pierre Baduel, Vincent Colot, Tetsuji Kakutani, Leandro Quadrana
Přispěvatelé: The University of Tokyo (UTokyo), Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Japanese Society for the Promotion of Science (JSPS) KAKENHI grant numbers JP18K06348 to TS, 26221105, 15H05963, and 19H00995 to TK, Japan Science Technology Agency (JST) CREST Grant (JPMJCR15O1 to TK)Centre National de la Recherche Scientifique (IRP SYNERTE, to LQ)the European Union Seventh Framework Programme Network of Excellence EpiGeneSys (Award 257082) the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No.948674 the Fondation pour la Recherche Medicale (FRM)Investissements d’Avenir ANR-10-LABX-54 MEMO LIFE, 506 ANR-11-IDEX-0001-02 PSL* Research University, Fondation pour la Recherche Médicale (FRM), ANR-10-LABX-0054,MEMOLIFE,Memory in living systems: an integrated approach(2010), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), European Project: 257082,EC:FP7:HEALTH,FP7-HEALTH-2010-two-stage,EPIGENESYS(2010)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Arabidopsis
General Biochemistry
Genetics and Molecular Biology
Epigenesis
Genetic
[SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics
anti-silencing
Gene Expression Regulation
Plant
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
evolution
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Gene Silencing
RNA
Small Interfering
Molecular Biology
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
General Immunology and Microbiology
epigenetics
General Neuroscience
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
food and beverages
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
Articles
DNA Methylation
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
DNA Transposable Elements
transposable elements
Genome
Plant
Zdroj: EMBO J
EMBO Journal
EMBO Journal, 2022, 41 (8), ⟨10.15252/embj.2021110070⟩
EMBO Journal, 2022, 41 (8), pp.1-15. ⟨10.15252/embj.2021110070⟩
ISSN: 0261-4189
1460-2075
Popis: International audience; Transposable elements (TEs) constitute a major threat to genome stability and are therefore typically silenced by epigenetic mechanisms. In response, some TEs have evolved counteracting systems to suppress epigenetic silencing. In the model plant Arabidopsis thaliana, two such anti-silencing systems have been identified and found to be mediated by the VANC DNA-binding proteins encoded by VANDAL transposons. Here, we show that anti-silencing systems have rapidly diversified since their origin in eudicots by gaining and losing VANC-containing domains, such as DUF1985, DUF287, and Ulp1, as well as target sequence motifs. We further demonstrate that these motifs determine anti-silencing specificity by sequence, density, and helical periodicity. Moreover, such rapid diversification yielded at least 10 distinct VANC-induced anti-silencing systems in Arabidopsis. Strikingly, anti-silencing of non-autonomous VANDALs, which can act as reservoirs of 24-nt small RNAs, is critical to prevent the demise of cognate autonomous TEs and to ensure their propagation. Our findings illustrate how complex co-evolutionary dynamics between TEs and host suppression pathways have shaped the emergence of new epigenetic control mechanisms.
Databáze: OpenAIRE
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