Spermidine and spermine exert protective effects within the lung
Autor: | Remo Frei, Weronika Barcik, Anita Dreher, Krzysztof Krawczyk, Marcin Wawrzyniak, Patrick Westermann, Benoit Pugin, Ruth Ferstl, David Groeger, Marek Jutel, Paulina Wawrzyniak, Cezmi A. Akdis, Michael Scharl, Liam O’ Mahony |
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Přispěvatelé: | University of Zurich, O'Mahony, Liam |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Lipopolysaccharides
Lipopolysaccharide spermine polyamines Spermine 610 Medicine & health Inflammation RM1-950 Pharmacology Peripheral blood mononuclear cell 3000 General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_compound 10183 Swiss Institute of Allergy and Asthma Research spermidine medicine Animals Humans mouse models General Pharmacology Toxicology and Pharmaceutics Lung Cells Cultured House dust mite biology Pyroglyphidae Original Articles Allergens asthma biology.organism_classification respiratory tract diseases Mice Inbred C57BL Spermidine Disease Models Animal 10219 Clinic for Gastroenterology and Hepatology Neurology chemistry 2808 Neurology Leukocytes Mononuclear Cytokines Female Original Article Cytokine secretion Therapeutics. Pharmacology medicine.symptom Polyamine Bronchoalveolar Lavage Fluid |
Zdroj: | Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021) Pharmacology Research & Perspectives |
ISSN: | 2052-1707 |
Popis: | Asthma is a heterologous disease that is influenced by complex interactions between multiple environmental exposures, metabolism, and host immunoregulatory processes. Specific metabolites are increasingly recognized to influence respiratory inflammation. However, the role of protein‐derived metabolites in regulating inflammatory responses in the lung are poorly described. The aims of the present study were to quantify polyamine levels in bronchoalveolar lavages (BALs) from healthy volunteers and asthma patients, and to evaluate the impact of each polyamine on inflammatory responses using in vitro models and in a house dust mite (HDM)‐induced respiratory allergy model. Spermidine levels were decreased, while cadaverine levels were increased in BALs from asthma patients compared to healthy controls, using Ultra Performance Liquid Chromatography (UPLC). Both spermine and spermidine inhibit lipopolysaccharide (LPS)‐induced cytokine secretion from human peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) in vitro. In addition, oral gavage with spermine or spermidine modulate HDM‐induced cell infiltration, cytokine secretion, and epithelial cell tight junction expression in murine models. Spermidine also reduces airway hyper‐responsiveness. These results suggest that modulation of polyamine metabolism, in particular spermidine, is associated with respiratory inflammation and these molecules and pathways should be further explored as biomarkers of disease and potential targets for novel therapies. Spermine and spermidine display anti‐inflammatory effects using in vitro models and protect against house dust mite (HDM) extract‐induced airway inflammation in murine models. |
Databáze: | OpenAIRE |
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