Spermidine and spermine exert protective effects within the lung

Autor: Remo Frei, Weronika Barcik, Anita Dreher, Krzysztof Krawczyk, Marcin Wawrzyniak, Patrick Westermann, Benoit Pugin, Ruth Ferstl, David Groeger, Marek Jutel, Paulina Wawrzyniak, Cezmi A. Akdis, Michael Scharl, Liam O’ Mahony
Přispěvatelé: University of Zurich, O'Mahony, Liam
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Lipopolysaccharides
Lipopolysaccharide
spermine
polyamines
Spermine
610 Medicine & health
Inflammation
RM1-950
Pharmacology
Peripheral blood mononuclear cell
3000 General Pharmacology
Toxicology and Pharmaceutics
chemistry.chemical_compound
10183 Swiss Institute of Allergy and Asthma Research
spermidine
medicine
Animals
Humans
mouse models
General Pharmacology
Toxicology and Pharmaceutics
Lung
Cells
Cultured
House dust mite
biology
Pyroglyphidae
Original Articles
Allergens
asthma
biology.organism_classification
respiratory tract diseases
Mice
Inbred C57BL
Spermidine
Disease Models
Animal
10219 Clinic for Gastroenterology and Hepatology
Neurology
chemistry
2808 Neurology
Leukocytes
Mononuclear
Cytokines
Female
Original Article
Cytokine secretion
Therapeutics. Pharmacology
medicine.symptom
Polyamine
Bronchoalveolar Lavage Fluid
Zdroj: Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
ISSN: 2052-1707
Popis: Asthma is a heterologous disease that is influenced by complex interactions between multiple environmental exposures, metabolism, and host immunoregulatory processes. Specific metabolites are increasingly recognized to influence respiratory inflammation. However, the role of protein‐derived metabolites in regulating inflammatory responses in the lung are poorly described. The aims of the present study were to quantify polyamine levels in bronchoalveolar lavages (BALs) from healthy volunteers and asthma patients, and to evaluate the impact of each polyamine on inflammatory responses using in vitro models and in a house dust mite (HDM)‐induced respiratory allergy model. Spermidine levels were decreased, while cadaverine levels were increased in BALs from asthma patients compared to healthy controls, using Ultra Performance Liquid Chromatography (UPLC). Both spermine and spermidine inhibit lipopolysaccharide (LPS)‐induced cytokine secretion from human peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) in vitro. In addition, oral gavage with spermine or spermidine modulate HDM‐induced cell infiltration, cytokine secretion, and epithelial cell tight junction expression in murine models. Spermidine also reduces airway hyper‐responsiveness. These results suggest that modulation of polyamine metabolism, in particular spermidine, is associated with respiratory inflammation and these molecules and pathways should be further explored as biomarkers of disease and potential targets for novel therapies.
Spermine and spermidine display anti‐inflammatory effects using in vitro models and protect against house dust mite (HDM) extract‐induced airway inflammation in murine models.
Databáze: OpenAIRE
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