Genotype and allele frequencies of polymorphic cytochromes P450CYP1A2 andCYP2E1 in Mexicans
| Autor: | Roberto Martínez-Hernández, Mario Bermudez, Arnulfo Albores, Juan E. Salinas, Fabiola Castorena-Torres, Ania Mendoza-Cantú, Arturo Ortega |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Gene isoform Adolescent Genotype Clinical Biochemistry Mutant Polymerase Chain Reaction Biochemistry chemistry.chemical_compound Gene Frequency Cytochrome P-450 CYP1A2 Humans Mexico Allele frequency Genetics biology CYP1A2 Cytochrome P450 Cytochrome P-450 CYP2E1 Cell Biology General Medicine Middle Aged Molecular biology Minor allele frequency chemistry Mutation biology.protein Female Xenobiotic Polymorphism Restriction Fragment Length |
| Zdroj: | Cell Biochemistry and Function. 22:29-34 |
| ISSN: | 1099-0844 0263-6484 |
| DOI: | 10.1002/cbf.1049 |
| Popis: | CYP1A2 and CYP2E1 are two of the main cytochrome P450 isoforms involved in the metabolism of commonly used drugs and xenobiotic compounds considered to be responsible for or possible participants in the development of several human diseases. Individual susceptibility to developing these pathologies relies, among other factors, on genetic polymorphism which depends on ethnic differences, as the frequency of mutant genotypes varies in different human populations. Thus the aim of this study was to investigate the frequency of CYP1A2 5'-flanking region and CYP2E1 Rsa I/Pst I polymorphisms in Mexicans by PCR-RFLP methods. The DNA of 159 subjects was analysed and mutant allele frequencies of 30% for CYP2E1 Rsa I/Pst I sites and 43% for CYP1A2 5'-flanking region were found. These frequencies are higher than those previously reported for other human populations. |
| Databáze: | OpenAIRE |
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