'On-off' syndrome treated with lithium carbonate: a case report
| Autor: | Ferren El, Walker Ji, Olanow Cw, Ross Dr, Coffey Ce |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Lithium (medication) medicine.medical_treatment Lithium Gastroenterology Receptors Dopamine Levodopa chemistry.chemical_compound Lithium Carbonate Chorea Postsynaptic potential Internal medicine medicine Humans Effective treatment Athetosis Desensitization (medicine) business.industry Parkinsonism Lithium carbonate Parkinson Disease medicine.disease Pathophysiology Psychiatry and Mental health chemistry Dopamine receptor Anesthesia business medicine.drug |
| Zdroj: | American Journal of Psychiatry. 138:1626-1627 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/ajp.138.12.1626 |
| Popis: | The authors describe a 42-year-old man who developed ‘ ‘onoff’ ‘ episodes and for whom lithium carbonate proved an effective treatment. They speculate that the predominant effect of lithium in the ‘ ‘on-off ‘ syndrome is to prevent Ldopa desensitization of the dopamine receptor. The “on-off” syndrome is a severe movement disorder characterized by alternating states of akinesia and choreoathetotic dyskinesias. The syndrome occurs in 1 1%-50% of patients with Parkinson’s disease who have received L-dOpa therapy for more than 2 years, and it is felt to represent the progression of the underlying parkinsonism complicated by an acquired alteration in responsiveness to the drug. The patient is either not receiving therapeutic benefit (the “off” or akinetic state) or has suddenly developed a toxic reaction to L-dopa (the “on” or dyskinetic state). The pathophysiology may reflect alternating states of postsynaptic dopamine receptor supersensitivity and hy |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|