Chronic Inflammation Impairs Male Fertility—A Case-Control Study in Ulcerative Colitis Patients
Autor: | Joanna Bartosińska, Rafał Filip, Dorota Raczkiewicz, Anita Wdowiak-Filip, Mariusz Gujski, Iwona Bojar, Artur Wdowiak |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
endocrine system lcsh:Medicine Semen Semen analysis Inflammatory bowel disease Gastroenterology Article Enterococcus faecalis semen analysis 03 medical and health sciences antisperm antibodies 0302 clinical medicine inflammatory bowel disease male sex hormones Internal medicine medicine oxidation-reduction potential ulcerative colitis 030219 obstetrics & reproductive medicine biology medicine.diagnostic_test business.industry urogenital system lcsh:R Case-control study bacterial infection General Medicine medicine.disease biology.organism_classification Ulcerative colitis Sperm DNA fragmentation 030211 gastroenterology & hepatology business |
Zdroj: | Journal of Clinical Medicine Volume 10 Issue 7 Journal of Clinical Medicine, Vol 10, Iss 1460, p 1460 (2021) |
ISSN: | 2077-0383 |
DOI: | 10.3390/jcm10071460 |
Popis: | Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. The control group consists of 50 healthy volunteers. Total sperm count, sperm count, percentage of morphologically normal spermatozoa, viability, and progressive motility, are significantly lower in the study group than in healthy males (p < 0.001). The DNA fragmentation index (DFI) and oxidation-reduction potential (ORP) are significantly higher in the study group (28.9% and 1.55% on average, respectively) than in healthy males (14.6% and 0.79% on average, respectively). Bacteriospermia is more clearly observed in the study group (p = 0.037), and the most frequent pathogen is Enterococcus faecalis. The DFI and ORP are significantly higher in bacteria carriers, compared to males without microbial pathogens from both the study and control groups (p < 0.001). To conclude, UC patients have worse basic sperm parameters compared to their healthy counterparts. Deterioration of semen parameters, as well as an intensified DNA fragmentation could be a result of oxidative stress intensification. |
Databáze: | OpenAIRE |
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