MiR-613 Promotes Cell Death in Breast Cancer Cells by Downregulation of Nicotinamide Phosphoribosyltransferase and Reduction of NAD

Autor:	Parisa Aziminezhadan, Zohreh Abdolvahabi, Shahin Alizadeh-Fanalou, Masoumeh Tavakoli-Yaraki, Saman Hosseinkhani, Mitra Nourbakhsh, Meysam Abolmaali, Samira Ezzati-Mobaser, Zahra Hesari, Ali Nazarizadeh
Rok vydání:	2021
Předmět:	Adult 0301 basic medicine Programmed cell death Cell Survival Nicotinamide phosphoribosyltransferase Apoptosis Breast Neoplasms Iran Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation Cell Line Tumor Genetics Humans Nicotinamide Phosphoribosyltransferase Molecular Biology Nucleotide salvage chemistry.chemical_classification Cell Death Cell Biology General Medicine Metabolism Middle Aged NAD MicroRNAs 030104 developmental biology Enzyme chemistry 030220 oncology & carcinogenesis Cancer research Cytokines Female NAD+ kinase
Zdroj:	DNA and Cell Biology. 40:1026-1036
ISSN:	1557-7430 1044-5498
DOI:	10.1089/dna.2021.0330
Popis:	NAD is mainly biosynthesized by the enzymatic action of nicotinamide phosphoribosyltransferase (NAMPT) through the salvage pathway. NAD is indispensable for the proper function and metabolism of all living cells, including cancer cells. Our previous researches revealed that inhibition of
Databáze:	OpenAIRE
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