Nephrectomy Modifies Renal Angiotensin II Effects in Kidney Donors
| Autor: | Elena Spada, Silvano Milani, Mariagrazia Cozzi, E Guidi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Efferent arteriole medicine.medical_specialty Time Factors medicine.medical_treatment Urology Renal function Blood Pressure Kidney urologic and male genital diseases Nephrectomy Renal Circulation Internal medicine Living Donors Internal Medicine medicine Animals Humans Infusions Parenteral Renal Insufficiency Kidney surgery Renal circulation business.industry Hemodynamics Models Cardiovascular Effective renal plasma flow Middle Aged Adaptation Physiological Kidney Transplantation Angiotensin II Angiotensin Amide medicine.anatomical_structure Endocrinology Disease Progression Cattle Female Vascular Resistance business Glomerular Filtration Rate |
| Zdroj: | American Journal of Hypertension. 21:592-598 |
| ISSN: | 1941-7225 0895-7061 |
| Popis: | Background Age, gender, menopausal status, a family history of hypertension, and renal vascular response to angiotensin II are involved in the progression of renal failure from its very beginning. Methods In order to investigate their importance on this progression, we measured effective renal plasma flow (ERPF) and glomerular filtration rate (GFR), and calculated glomerular pressure (Pglo) and afferent and efferent arteriole resistances (by means of Gomez formulae) in 26 normotensive kidney donors before and after nephrectomy. Results Renal reactivity to angiotensin was the only variable that affected changes in renal and glomerular hemodynamics after the loss of renal tissue: in subjects with greater angiotensin reactivity, higher afferent resistances (Ra) and lower glomerular filtration and pressure before nephrectomy change to higher efferent resistances (Re) and higher Pglo and filtration after nephrectomy. Conclusions In normotensive donors with a normal compensatory response to nephrectomy, baseline renal reactivity to angiotensin II can influence renal and glomerular hemodynamics 1 year after nephrectomy. |
| Databáze: | OpenAIRE |
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