Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study

Autor: Minas Leventis, Danai Anna Papavasileiou, Orestis Vasiliadis, Antonios Galanos, Peter Fairbairn, Chas Mangham, Robert A. Horowitz
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Animal study
Pathology
medicine.medical_specialty
bone substitutes
chemistry.chemical_element
Calvaria
02 engineering and technology
Bone healing
Calcium
Bone tissue
lcsh:Technology
Article
calcium sulfate
03 medical and health sciences
0302 clinical medicine
stomatognathic system
bone regeneration
medicine
General Materials Science
Bone regeneration
lcsh:Microscopy
lcsh:QC120-168.85
Bone substitutes
Manchester Cancer Research Centre
lcsh:QH201-278.5
business.industry
lcsh:T
Calcium sulfate
ResearchInstitutes_Networks_Beacons/mcrc
Histology
030206 dentistry
021001 nanoscience & nanotechnology
equipment and supplies
animal study
β-tricalcium phosphate
Resorption
medicine.anatomical_structure
chemistry
lcsh:TA1-2040
Orthopedic surgery
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
0210 nano-technology
business
lcsh:Engineering (General). Civil engineering (General)
lcsh:TK1-9971
Zdroj: Materials, Vol 11, Iss 10, p 2004 (2018)
Materials
Volume 11
Issue 10
Leventis, M, Fairbairn, P, Mangham, C, Galanos, A, Vasiliadis, O, Papavasileiou, D & Horowitz, R 2018, ' Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study ', Materials, vol. 11, no. 10, 2004, pp. 2004 . https://doi.org/10.3390/ma11102004
ISSN: 1996-1944
DOI: 10.3390/ma11102004
Popis: Bioactive alloplastic materials, like beta-tricalcium phosphate (&beta
TCP) and calcium sulfate (CS), have been extensively researched and are currently used in orthopedic and dental bone regenerative procedures. The purpose of this study was to compare the performance of EthOss versus a bovine xenograft and spontaneous healing. The grafting materials were implanted in standardized 8 mm circular bicortical bone defects in rabbit calvariae. A third similar defect in each animal was left empty for natural healing. Six male rabbits were used. After eight weeks of healing, the animals were euthanized and the bone tissue was analyzed using histology and micro-computed tomography (micro-CT). Defects treated with &beta
TCP/CS showed the greatest bone regeneration and graft resorption, although differences between groups were not statistically significant. At sites that healed spontaneously, the trabecular number was lower (p <
0.05) and trabecular separation was higher (p <
0.05), compared to sites treated with &beta
TCP/CS or xenograft. Trabecular thickness was higher at sites treated with the bovine xenograft (p <
0.05) compared to sites filled with &beta
TCP/CS or sites that healed spontaneously. In conclusion, the novel &beta
TCP/CS grafting material performed well as a bioactive and biomimetic alloplastic bone substitute when used in cranial defects in this animal model.
Databáze: OpenAIRE
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